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(CLEVERHEART) University Interventional Core Laboratories

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CLEVERHEART University Interventional Core Laboratories: Pioneering

Cardiovascular Research in Gdańsk, Poland

CLinical EVidencE-based Research in HEART and Vascular Medicine


ABOUT US

CLEVERHEART University Interventional Core Laboratories, located in Gdańsk, Poland, is a pioneering center dedicated to optimizing and developing novel therapies in invasive cardiology. As a unique European-scale institution, our focus includes:

  • Comprehensive coronary artery revascularization using advanced intravascular imaging.
  • Percutaneous diagnosis and treatment of structural heart diseases, including heart failure.
  • Functional assessment of coronary vessels and microcirculation.

Our center is built on the extensive experience of the team from the 1st Chair and Department of Cardiology at the University Clinical Centre of the Medical University of Gdańsk. We collaborate closely with the newly established Centre for Translational Medicine (CMT) to integrate artificial intelligence and metabolomics into cardiovascular therapy, establishing a cutting-edge facility for personalized patient care.

The University Interventional Core Laboratories works closely with the newly established Biostatistics and Bioinformatics Core Facility.


INFRASTRUCTURE AND CAPABILITIES

The center will be equipped with state-of-the-art technology, ensuring top-tier diagnostics and therapies for cardiovascular diseases. Key infrastructure developments include:

  • A hybrid treatment room integrating X-ray and tomographic imaging.
  • Advanced perioperative care facilities.
  • A professional base for research, project meetings, and treatment analysis.

Advanced infrastructure for 24-hour hemodynamic monitoring during and after surgical procedures, as well as archiving of perioperative data, will be implemented.Our capabilities will be further enhanced by the newly established Clinical Research Support Centre (CWBK), and we will operate under the IDUB (Excellence Initiative – Research University) in Priority Research Areas (POB 2).

Planned Equipment Acquisitions

The planned purchase of cutting-edge equipment includes:

  • Optis I: An innovative system combining Optical Coherence Tomography (OCT) and Fractional Flow Reserve (FFR) measurement.
  • CoroFlow: An integrated system for functional assessment of coronary artery lesions and microcirculation.
  • High-resolution imaging systems for precise stent visualization and 3D coronary imaging.

Aforementioned equipments will significantly increase the precision of procedures, allowing the possibility of integrated analysis of stenosis and functional evaluation of coronary artery disease. Additionally, assessment of coronary microcirculation and the possibility of high-resolution stent visualization that offers co-registration of X-ray and tomographic images and high-resolution 3D imaging (DynaCT Micro).


RESEARCH AND DEVELOPMENT OBJECTIVES

LEVERHEART’s research agenda includes the integration of complementary imaging modalities—such as intravascular ultrasound (IVUS), OCT, FFR measurement, and invasive microcirculation assessment—facilitating a comprehensive analysis of atherosclerotic plaque morphology and functional significance of coronary stenosis. These capabilities will improve the diagnosis and treatment of complex coronary pathologies and optimize percutaneous coronary intervention (PCI) and stent implantation.

System for integrated functional assessment of lesions in coronary arteries and coronary microcirculation (Coroventis CoroFlow ™, Sweden) enables FFR or instantaneous wave-free ratio (iFR), index of microcirculatory resistance (IMR), coronary flow reserve (CFR) and resistive reserve ratio (RRR), as well as an assessment of myocardial diastolic function based on relaxation time and end-diastolic pressure. Integration of data obtained from these methods will optimize the diagnosis of cardiovascular diseases, and a significant increase in therapeutic precision will not only enable the identification of patients at high risk of a coronary incident, improving significantly the prognosis.

One of our key research objectives is to develop algorithms for the automatic detection of high-risk coronary lesions using intravascular imaging. Through the fusion of angiographic and echocardiographic images, we aim to pioneer international research in structural heart disease diagnostics and treatment, leveraging artificial intelligence to enhance decision-making during interventions such as transcatheter aortic valve implantation (TAVI) and percutaneous mitral valve repair using the MitraClip system.

Collaborative Projects

In collaboration with Polimed, our team is engaged in the development of a novel, flow-modulated atrial implant intended to improve the quality of life and exercise tolerance in patients with advanced heart failure. This device, which is being designed as a permanent solution to connect the atria, has the potential to significantly reduce hospitalization rates by improving cardiac function in patients with severe heart failure.

Our research also includes planned multicenter, randomized, double-blind, placebo-controlled trials using the Coroventis CoroFlow™ system. These trials aim to validate a novel therapeutic strategy for patients with angina pectoris in the absence of significant coronary artery disease, potentially revolutionizing treatment guidelines established by the European Society of Cardiology.

International Collaboration

CLEVERHEART’s research is underpinned by collaborations with leading experts in invasive cardiology, including prominent figures such as

Prof. Juan Luis Gutierrez-Chico (Spain), Prof. Thomas Luescher (UK), Prof. Christian Templin (Switzerland), Prof. Salvatore Brugaletta (Spain), Prof. Patrick Serruys (UK), Rienk Nieuwland, PhD (The Netherlands), Prof. Jolanta Siller-Matula (Austria), Prof. Tomasz Smoleński (Poland), Prof. Shmuel Banai (Israel), Prof. Amir Lerman (USA), Prof. Richard Heuser (USA), Prof. Dagmara Hering (Poland), Prof. Łukasz Szarpak (Poland).


OUR MISSION

The CLEVERHEART Interventional Core Laboratories aspire to become a premier research and development center, offering an attractive environment for scientists and serving as a collaborative partner for international scientific and commercial projects. We aim to be at the forefront of designing, patenting, and evaluating the safety and efficacy of novel diagnostic and therapeutic technologies in cardiology.

Relevance to Innovation and Economic Development

Cardiovascular diseases remain the leading cause of mortality worldwide, accounting for over 30% of deaths annually. Our research aims to address this challenge by developing and optimizing interventional cardiology procedures for both acquired and congenital heart diseases, in alignment with the objectives of the National Health Programme, including the promotion of healthy and active aging.

The development of innovative diagnostic and therapeutic solutions at CLEVERHEART will not only improve patient outcomes but also reduce healthcare costs associated with recurrent cardiovascular events and long-term care. By improving the health and quality of life of patients, we will contribute to significant economic savings at a relatively low cost.


RESEARCH PROFILE

CLEVERHEART Interventional Core Laboratories will be equipped with cutting-edge infrastructure and supported by a team of cardiologists with extensive experience in both coronary and structural heart disease interventions. Our team, under the leadership of renowned experts such as Prof. Miłosz Jaguszewski, will facilitate the conduct of both commercial and non-commercial research programs in collaboration with international and domestic companies developing new therapeutic devices.

Key Research Capabilities

1. State-of-the-art infrastructure dedicated to cardiovascular research.

2. A multidisciplinary team of experts, including:

  • Dr. Dariusz Ciećwierz, a pioneer of invasive cardiology in Northern Poland.
  • Prof. Miłosz Jaguszewski, a prolific researcher with over 180 scientific publications.
  • Prof. Łukasz Szarpak, an expert in emergency and acute cardiology.
  • Prof. Marcin Gruchała, a leading authority on heart failure.
  • Prof. Marcin Fijałkowski, a specialist in cardiovascular imaging.
  • Prof. Tomasz Smoleński, an expert in experimental cardiology.
  • Prof. Paul Grundeman, a visiting professor from Utrecht specializing in experimental cardiac surgery.

3. Collaboration with the Centre for Translational Medicine (CMT), the University Clinical Centre, Gdańsk University of Technology, and leading equipment manufacturers, positioning us to build a leading research and development center in Europe.

Ongoing and Planned Research

The CardioResearch Group, established in 2020, leads CLEVERHEART’s research efforts, focusing on conceptual scientific projects and clinical research with an emphasis on non-commercial clinical trials. Current research includes several non-commercial clinical trials, such as:

1. ADONIS-PCI: A prospective, randomized, open-label trial evaluating the safety and efficacy of dual anticoagulation therapy with dabigatran and ticagrelor in acute coronary syndrome patients undergoing percutaneous coronary intervention.

2. ELECTRA SIRO 2: A multicentre, double-blind trial assessing two antiplatelet de-escalation strategies in patients with acute coronary syndrome.

3. EMPATHY: A placebo-controlled trial comparing the prognostic impact of two antidiabetic drugs in patients with acute heart failure.

4. HEMOFLOW: An evaluation of the diagnostic accuracy, safety, and cost-effectiveness of noninvasive fractional flow reserve (FFR) measurement methods.

5. LEIA-HF: A randomized, placebo-controlled study on the efficacy of repeated levosimendan infusions in patients with advanced systolic heart failure.

6. MULTISTARS AMI: A study comparing two treatment strategies for acute myocardial infarction patients.



Future Directions

In addition to these ongoing projects, we are preparing a grant application for the LevoTako Study, a randomized, placebo-controlled trial to assess the effects of levosimendan on patients with Takotsubo syndrome. Moreover, our conceptual work includes the CLEVERSTENT Project, which aims to develop a new drug-eluting stent (DES) with anti-inflammatory properties to treat atherosclerotic lesions more effectively.

The CLEVERHEART Network, an initiative co-founded by leading experts in cardiovascular medicine, seeks to accelerate knowledge exchange and foster collaboration in cardiovascular research, ultimately leading to a more personalized approach to patient care.


OUR TEAM


prof._Jaguszewski_fot._Paweł_Sudara_GUMed.jpg

Team Leader

Miłosz Jaguszewski, professor of medical and health science, president of 30 PTK Club, graduate of Medical University of Gdańsk (2007); attended scientific internships at the Department of Cardiology, University Heart Centre based at the University Hospital Zurich and Department of Cardiology, University Hospital Berlin (Benjamin Franklin Campus) (2010-2015); editor-in-chief of Cardiology Journal, author of over 180 scientific publications, IF >800, i-H 20/25 (WoS, Scopus); main clinical and scientific interests: percutaneous intravascular procedures with the use of modern interventional methods, percutaneous recanalization of chronic coronary total occlusions, coronary bioresorbable scaffolds, intravascular imaging (IVUS, OCT), renal artery denervation and Takotsubo cardiomyopathy.




Team Members

Steering Committee

  • Prof. Miłosz J. Jaguszewski, Founder
  • Prof. Aleksandra Gasecka
  • Prof. Lukasz Szarpak
  • Dr. Natasza Gilis-Malinowska

Team Members

  • Prof. Agnieszka Mickiewicz
  • Dr. Radosław Targoński
  • Dr Grzegorz Żuk
  • Dr Maksymilian Mielczarek
  • Dr Michał Chmielecki
  • Dr Jakub Kiedrzyn
  • Dr Piotr Kasprzyk
  • Dr Tomasz Figatowski
  • Dr Zuzanna Lewicka

ADVISORY BOARD MEMBERS

  • Prof. Christian Templin
  • Prof. Juan Luis Guttierrez-Chico
  • Prof. Paul Grundemann

Scientific achievements of the CardioResearchGroup

Since its inception in 2020, CardioResearchGroup team members have published extensively in peer-reviewed scientific journals including Q1 journals such as European Heart Journal (IF: 22,673) and Journal of American College of Cardiology (IF: 20.589).


OUR PUBLICATIONS

2024

Schweiger, V., Di Vece, D., Cammann, V. L., Koleva, I., Würdinger, M., Gilhofer, T., Rajman, K., Szawan, K. A., Niederseer, D., Citro, R., Vecchione, C., Bossone, E., Gili, S., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., . . . Templin, C. (2024b). Cardiac biomarkers for diagnosing Takotsubo syndrome. European Heart Journal, 45(25), 2254–2258. https://doi.org/10.1093/eurheartj/ehae231

Azizi, M., Sharp, A. S., Fisher, N. D., Weber, M. A., Lobo, M. D., Daemen, J., Lurz, P., Mahfoud, F., Schmieder, R. E., Basile, J., Bloch, M. J., Saxena, M., Wang, Y., Sanghvi, K., Jenkins, J. S., Devireddy, C., Rader, F., Gosse, P., Claude, L., . . . Renkin, J. (2023). Patient-Level pooled analysis of endovascular ultrasound renal denervation or a sham procedure 6 months after medication escalation: the RADIANCE Clinical Trial program. Circulation, 149(10), 747–759. https://doi.org/10.1161/circulationaha.123.066941

Schweiger, V., Cammann, V. L., Crisci, G., Gilhofer, T., Schlenker, R., Niederseer, D., Chen, S., Ebrahimi, R., Wenzl, F., Würdinger, M., Citro, R., Vecchione, C., Gili, S., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., . . . Di Vece, D. (2024b). Temporal trends in Takotsubo Syndrome. Journal of the American College of Cardiology, 84(13), 1178–1189. https://doi.org/10.1016/j.jacc.2024.05.076

De Filippo, O., Wańha, W., Sanavia, T., Januszek, R., Giacobbe, F., Campo, G., Pinxterhuis, T. H., Capodanno, D., Tomasiewicz, B., Iannaccone, M., Leone, A., Wolny, R., Bruno, F., Patti, G., Musumeci, G., Liccardo, G., Verardi, R., Roubin, S. R., Tarantini, G., . . . D’Ascenzo, F. (2024b). Treatment of in-stent restenosis with ultrathin-strut versus thin-strut drug-eluting stents or drug-eluting balloons: a multicentre registry. PubMed, 20(21), e1340–e1354. https://doi.org/10.4244/eij-d-24-00491

Wańha, W., Iwańczyk, S., Januszek, R., Wolny, R., Tomasiewicz, B., Kuliczkowski, W., Reczuch, K., Pawlus, P., Pawłowski, T. Z., Kuźma, Ł., Kubler, P., Niezgoda, P., Kubica, J., Gil, R. J., Pawłowski, T. F., Gąsior, M., Jaguszewski, M., Wybraniec, M., Witkowski, A., . . . Cortese, B. (2024b). Long-Term outcomes following Sirolimus-Coated balloon or Drug-Eluting stents for treatment of In-Stent restenosis. Circulation Cardiovascular Interventions. https://doi.org/10.1161/circinterventions.124.014064

Jaguszewski, M. J., Pruc, M., & Szarpak, L. (2024b). The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive. European Journal of Internal Medicine. https://doi.org/10.1016/j.ejim.2024.08.013

2023

Kirtane, A. J., Sharp, A. S. P., Mahfoud, F., Fisher, N. D. L., Schmieder, R. E., Daemen, J., Lobo, M. D., Lurz, P., Basile, J., Bloch, M. J., Weber, M. A., Saxena, M., Wang, Y., Sanghvi, K., Jenkins, J. S., Devireddy, C., Rader, F., Gosse, P., Sapoval, M., . . . Owczuk, R. (2023c). Patient-Level pooled analysis of ultrasound renal denervation in the SHAM-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO trials. JAMA Cardiology, 8(5), 464. https://doi.org/10.1001/jamacardio.2023.0338

Stähli, B. E., Varbella, F., Linke, A., Schwarz, B., Felix, S. B., Seiffert, M., Kesterke, R., Nordbeck, P., Witzenbichler, B., Lang, I. M., Kessler, M., Valina, C., Dibra, A., Rohla, M., Moccetti, M., Vercellino, M., Gaede, L., Bott-Flügel, L., Jakob, P., . . . Ruschitzka, F. (2023b). Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction. New England Journal of Medicine, 389(15), 1368–1379. https://doi.org/10.1056/nejmoa2307823

Borghi, C., Domienik-Karłowicz, J., Tykarski, A., Filipiak, K. J., Jaguszewski, M. J., Narkiewicz, K., Barylski, M., Mamcarz, A., Wolf, J., & Mancia, G. (2023). Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2023 update. Cardiology Journal, 31(1), 1–14. https://doi.org/10.5603/cj.98254

Denegri, A., Szarpak, L., Pruc, M., & Jaguszewski, M. J. (2023b). Spontaneous coronary artery dissection and Takotsubo syndrome. European Journal of Internal Medicine, 117, 137–139. https://doi.org/10.1016/j.ejim.2023.08.006

De Filippo, O., Cammann, V. L., Pancotti, C., Di Vece, D., Silverio, A., Schweiger, V., Niederseer, D., Szawan, K. A., Würdinger, M., Koleva, I., Dusi, V., Bellino, M., Vecchione, C., Parodi, G., Bossone, E., Gili, S., Neuhaus, M., Franke, J., Meder, B., . . . Templin, C. (2023c). Machine learning‐based prediction of in‐hospital death for patients with takotsubo syndrome: The InterTAK‐ML model. European Journal of Heart Failure, 25(12), 2299–2311. https://doi.org/10.1002/ejhf.2983

Stähli, B. E., Varbella, F., Linke, A., Schwarz, B., Felix, S. B., Seiffert, M., Kesterke, R., Nordbeck, P., Witzenbichler, B., Lang, I. M., Kessler, M., Valina, C., Dibra, A., Rohla, M., Moccetti, M., Vercellino, M., Gaede, L., Bott-Flügel, L., Jakob, P., . . . Ruschitzka, F. (2023). Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction. New England Journal of Medicine, 389(15), 1368–1379. https://doi.org/10.1056/nejmoa2307823

2022

Szarpak, L., Mierzejewska, M., Jurek, J., Kochanowska, A., Gasecka, A., Truszewski, Z., Pruc, M., Blek, N., Rafique, Z., Filipiak, K. J., Denegri, A., & Jaguszewski, M. J. (2022). Effect of Coronary Artery Disease on COVID-19—Prognosis and Risk Assessment: A Systematic Review and Meta-Analysis. Biology, 11(2), 221. https://doi.org/10.3390/biology11020221

Imori, Y., Kato, K., Cammann, V. L., Szawan, K. A., Wischnewsky, M., Dreiding, S., Würdinger, M., Schönberger, M., Petkova, V., Niederseer, D., Levinson, R. A., Di Vece, D., Gili, S., Seifert, B., Wakita, M., Suzuki, N., Citro, R., Bossone, E., Heiner, S., . . Templin, C. (2021). Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry. Clinical Research in Cardiology, 111(2), 186–196. https://doi.org/10.1007/s00392-021-01857-4

Nucera, G., Chirico, F., Rafique, Z., Gilis-Malinowska, N., Gasecka, A., Litvinova, N., Wang, B., Ilesanmi, O. S., Pruc, M., Jaguszewski, M. J., & Szarpak, L. (2021). Need to update cardiological guidelines to prevent COVID-19 related myocardial infarction and ischemic stroke. Cardiology Journal, 29(1), 174–175. https://doi.org/10.5603/cj.a2021.0120

Bielski, K., Böttiger, B. W., Pruc, M., Gasecka, A., Sieminski, M., Jaguszewski, M. J., Smereka, J., Gilis-Malinowska, N., Peacock, F. W., & Szarpak, L. (2022). Outcomes of audio-instructed and video-instructed dispatcher-assisted cardiopulmonary resuscitation: a systematic review and meta-analysis. Annals of Medicine, 54(1), 464–471. https://doi.org/10.1080/07853890.2022.2032314

Wańha, W., Tomaniak, M., Wańczura, P., Bil, J., Januszek, R., Wolny, R., Opolski, M. P., Kuźma, Ł., Janas, A., Figatowski, T., Gąsior, P., Milewski, M., Roleder-Dylewska, M., Lewicki, Ł., Kulczycki, J., Włodarczak, A., Tomasiewicz, B., Iwańczyk, S., Sacha, J., . . . Wojakowski, W. (2022). Intravascular lithotripsy for the treatment of stent underexpansion: the Multicenter IVL-DRAGON Registry. Journal of Clinical Medicine, 11(7), 1779. https://doi.org/10.3390/jcm11071779

Kubica, J., Ostrowska, M., Stolarek, W., Kasprzak, M., Grzelakowska, K., Kryś, J., Kubica, A., Adamski, P., Podhajski, P., Navarese, E. P., Anielska‐Michalak, E., Brycht, O., Curzytek, A., Dudek, A., Gromadziński, L., Grzelakowski, P., Kamiński, L., Kleinrok, A., Kostkiewicz, M., . . . Kaźmierczak, J. (2021). Impact of COVID‐19 pandemic on acute heart failure admissions and mortality: a multicentre study. ESC Heart Failure, 9(1), 721–728. https://doi.org/10.1002/ehf2.13680

Szarpak, L., Pruc, M., Filipiak, K. J., Popieluch, J., Bielski, A., Jaguszewski, M. J., Gilis-Malinowska, N., Chirico, F., Rafique, Z., & Peacock, F. W. (2021). Myocarditis: A complication of COVID-19 and long-COVID-19 syndrome as a serious threat in modern cardiology. Cardiology Journal, 29(1), 178–179. https://doi.org/10.5603/cj.a2021.0155

2021

Al-Jeabory M, Gasecka A, Wieczorek W, Mayer-Szary J, Jaguszewski MJ, Szarpak L. Efficacy and safety of tranexamic acid in pediatric trauma patients: Evidence from meta-analysis. Am J Emerg Med. 2021 Feb 8:S0735-6757(21)00115-7. doi: 10.1016/j.ajem.2021.02.009.

Borghi C, Domienik-Karłowicz J, Tykarski A, Widecka K, Filipiak KJ, Jaguszewski MJ, Narkiewicz K, Mancia G. Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update. Cardiol J. 2021;28(1):1-14. doi: 10.5603/CJ.a2021.0001.

Borkowska MJ, Smereka J, Safiejko K, Nadolny K, Maslanka M, Filipiak KJ, Jaguszewski MJ, Szarpak L. Out-of-hospital cardiac arrest treated by emergency medical service teams during COVID-19 pandemic: A retrospective cohort study. Cardiol J. 2021;28(1):15-22. doi: 10.5603/CJ.a2020.0135.

Drozd A, Smereka J, Filipiak KJ, Jaguszewski MJ, Ładny JR, Bielski K, Nadolny K, Ruetzler K, Szarpak Ł. Intraosseous versus intravenous access while wearing personal protective equipment: a meta-analysis in the era of COVID-19.:”https://pubmed.ncbi.nlm.nih.gov/33415967/” Kardiol Pol. 2021 Jan 7. doi: 10.33963/KP.15741

Gasecka A, Pruc M, Kukula K, Gilis-Malinowska N, Filipiak KJ, Jaguszewski MJ, Szarpak L. Post-COVID-19 heart syndrome. Cardiol J. 2021 Mar 1. doi: 10.5603/CJ.a2021.0028.

Gąsecka A, Pluta K, Solarska K, Rydz B, Eyileten C, Postula M, van der Pol E, Nieuwland R, Budnik M, Kochanowski J, Jaguszewski MJ, Szarpak Ł, Mazurek T, Kapłon-Cieślicka A, Opolski G, Filipiak KJ. Plasma Concentrations of Extracellular Vesicles Are Decreased in Patients with Post-Infarct Cardiac Remodelling. Biology (Basel). 2021 Jan 30;10(2):97. doi: 10.3390/biology10020097.

Jaguszewski MJ, Gasecka A, Filipiak KJ, Szarpak L. Levosimendan or dobutamine in patients with low cardiac output syndrome: Results from meta-analysis. Int J Cardiol. 2021 Feb 24:S0167527300359-4. doi: 10.1016/j.ijcard.2021.02.050.

Jaguszewski MJ, Szarpak L, Filipiak KJ. Impact of COVID-19 pandemic on out-of-hospital cardiac arrest survival rate. Resuscitation. 2021 Feb;159:40-41. doi: 10.1016/j.resuscitation.2020.12.013.

Kato K, Cammann VL, Napp LC, Szawan KA, Micek J, Dreiding S, Levinson RA, Petkova V, Würdinger M, Patrascu A, Sumalinog R, Gili S, Clarenbach CF, Kohler M, Wischnewsky M, Citro R, Vecchione C, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski MJ, Noutsias M, Knorr M, Heiner S, D’Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Kozel M, Tousek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Sano M, Ishibashi I, Takahara M, Himi T, Kobayashi Y, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Opolski G, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H, Borggrefe M, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, Crea F, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C. Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry. ESC Heart Fail. 2021 Mar 13. doi: 10.1002/ehf2.13165.

Kosmalska K, Rzyman M, Miękus P, Gilis-Malinowska N, Nowak R, Fijałkowski M. Usefulness of transesophageal echocardiography before cardioversion in atrial arrhythmias. Cardiol J. 2021;28(1):101-109. doi: 10.5603/CJ.a2019.0056.

Kulawiak-Gałąska DA, Gałąska R, Mielczarek M, Drewla P, Jaguszewski MJ, Fijałkowski M, Studniarek M. Pulmonary artery and left atrial appendage anatomical relationship using electrocardiogram-gated computed tomography: An important aspect of left atrial appendage occlusion. Cardiol J. 2021 Feb 26. doi: 10.5603/CJ.a2021.0024.

Lewicki L, Fijalkowska M, Karwowski M, Siebert K, Redlarski G, Palkowski A, Targonski R, Siebert J. The non-invasive evaluation of heart function in patients with an acute myocardial infarction: The role of impedance cardiography. Cardiol J. 2021;28(1):77-85. doi: 10.5603/CJ.a2019.0098

Ludwin K, Filipiak KJ, Jaguszewski MJ, Pruc M, Paprocki M, Smereka J, Szarpak L, Dabrowski M, Czekajlo M. Place of prefilled syringes in COVID-19 patient based on current evidence. Am J Emerg Med. 2021 Jan;39:234-235. doi: 10.1016/j.ajem.2020.05.016.

Melgarejo JD, Thijs L, Wei DM, Bursztyn M, Yang WY, Li Y, Asayama K, Hansen TW, Kikuya M, Ohkubo T, Dolan E, Stolarz-Skrzypek K, Cheng YB, Tikhonoff V, Malyutina S, Casiglia E, Lind L, Sandoya E, Filipovský J, Narkiewicz K, Gilis-Malinowska N, Kawecka-Jaszcz K, Boggia J, Wang JG, Imai Y, Verhamme P, Trenson S, Janssens S, Brien EO, Maestre GE, Gavish B, Staessen JA, Zhang ZY. Relative and Absolute Risk to Guide the Management of Pulse Pressure, an Age-Related Cardiovascular Risk Factor. Am J Hypertens. 2021 Mar 4:hpab048. doi: 10.1093/ajh/hpab048.

Melgarejo JD, Yang WY, Thijs L, Li Y, Asayama K, Hansen TW, Wei FF, Kikuya M, Ohkubo T, Dolan E, Stolarz-Skrzypek K, Huang QF, Tikhonoff V, Malyutina S, Casiglia E, Lind L, Sandoya E, Filipovský J, Gilis-Malinowska N, Narkiewicz K, Kawecka-Jaszcz K, Boggia J, Wang JG, Imai Y, Vanassche T, Verhamme P, Janssens S, O’Brien E, Maestre GE, Staessen JA, Zhang ZY; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcome Investigators. Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure. Hypertension. 2021 Jan;77(1):39-48. doi: 10.1161/HYPERTENSIONAHA.120.14929.

Merks P, Jakubowska M, Drelich E, Świeczkowski D, Bogusz J, Bilmin K, Sola KF, May A, Majchrowska A, Koziol M, Pawlikowski J, Jaguszewski M, Vaillancourt R. The legal extension of the role of pharmacists in light of the COVID-19 global pandemic. Res Social Adm Pharm. 2021 Jan;17(1):1807-1812. doi: 10.1016/j.sapharm.2020.05.033.

Merks P, Świeczkowski D, Balcerzak M, Religioni U, Drelich E, Krysiński J, Hering D, Jaguszewski MJ. Patient counselling service with the use of pictograms as the example of pharmacist intervention to improving compliance and medicine safety. Cardiol J. 2021 Feb 26. doi: 10.5603/CJ.a2021.0022.

Mickiewicz A, Marlega J, Kuchta A, Bachorski W, Cwiklinska A, Raczak G, Gruchala M, Fijalkowski M. Cardiovascular events in patients with familial hypercholesterolemia and hyperlipoproteinaemia (a): Indications for lipoprotein apheresis in Poland. J Clin Apher. 2021 Jan 2. doi: 10.1002/jca.21872.

Ruetzler K, Szarpak Ł, Ładny JR, Gąsecka A, Gilis-Malinowska N, Pruc M, Smereka J, Nowak B, Filipiak KJ, Jaguszewski MJ. D-dimer levels predict COVID-19 severity and mortality. Kardiol Pol. 2021 Feb 25;79(2):232-233. doi: 10.33963/KP.15830.

Szarpak L, Filipiak KJ, Gasecka A, Pruc M, Drozd A, Jaguszewski MJ. Correlation between takotsubo cardiomyopathy and SARS-CoV-2 infection. Med Hypotheses. 2021 Jan;146:110454. doi: 10.1016/j.mehy.2020.110454.

Szarpak L, Gasecka A, Opiełka M, Gilis-Malinowska N, Filipiak KJ, Jaguszewski MJ. Copeptin level differentiates takotsubo cardiomyopathy from acute myocardial infarction. Biomarkers. 2021 Mar;26(2):75-76. doi: 10.1080/1354750X.2021.1875503.

Szarpak Ł, Dzieciątkowski T, Jaguszewski MJ, Ładny JR, Filipiak KJ. Is remdesivir important in clinical practice as a treatment of COVID-19? A study based on meta-analysis data. Pol Arch Intern Med. 2021 Jan 29;131(1):96-97. doi: 10.20452/pamw.15686.

Szarpak Ł, Nowak B, Kosior D, Zaczynski A, Filipiak KJ, Jaguszewski MJ. Cytokines as predictors of COVID-19 severity: evidence from a meta-analysis. Pol Arch Intern Med. 2021 Jan 29;131(1):98-99. doi: 10.20452/pamw.15685.

Trela M, Szarpak Ł, Filipiak KJ, Meyer-Szary J, Gilis-Malinowska N, Nadolny K, Gąsecka A, Szarpak A, Smereka J, Jaguszewski MJ. Why epinephrine should not always be used in pediatric cardiac arrest? Kardiol Pol. 2021 Feb 25;79(2):235-236. doi: 10.33963/KP.15754.

Wilkowski M, Lewicki Ł, Olszewski R, Priebe A, Jaguszewski MJ, Szołkiewicz M. First-inhuman radiofrequency ablation of ventricular tachycardia performed through an Atrial Flow Regulator device. Cardiol J. 2021;28(1):161-162. doi: 10.5603/CJ.a2020.0172. Rok 2020

2020

Barycka K, Dzieciątkowski T, Drozd A, Szarpak Ł, Jaguszewski MJ, Filipiak KJ. Should emergency medical service stuff use respirators with filtered valve in COVID-19 pandemic? Adv. Respir. Med. 2020;88(6):638-639.

Barycka K, Szarpak L, Filipiak KJ, Jaguszewski MJ, Smereka J, Ladny JR, Turan O. Comparative effectiveness of N95 respirators and surgical/face masks in preventing airborne infections in the era of SARS-CoV2 pandemic: A meta-analysis of randomized trials. PLoS One 2020; 15(12):e0242901.

Barycka K, Torlinski T, Filipiak KJ, Jaguszewski MJ, Nadolny K., Szarpak Ł. Risk of selfcontamination among healthcare workers in the COVID-19 pandemic.. J. Emerg. Med. 2020. 10.1016/j.ajem.2020.09.055.

Borkowska MJ, Smereka J, Safiejko K, Nadolny, Maslanka M, Filipiak KJ, Jaguszewski MJ, Szarpak Ł. Out-of-hospital cardiac arrest treated by emergency medical service teams during COVID-19 pandemic: A retrospective cohort study. Kardiol. Pol. 2020;78(12):1254-1261.

Budnik M, Nowak R, Fijałkowski M, Kochanowski J, Nargiełło E, Piątkowski R, Peller M, Kucharz J, Jaguszewski MJ, Gruchała M, Opolski G. Sex-dependent differences in clinical characteristics and in-hospital outcomes in patients with takotsubo syndrome. Pol. Arch. Med. Wewn. 2020 : vol. 130, nr 1, s. 25-30.

Cammann VL, Szawan KA, Stähli BE, Kato K, Budnik M, Wischnewsky M, Dreiding S, Levinson RA, Di Vece D, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, *Jaguszewski MJ, Noutsias M, Knorr M, Heiner S, D’Ascenzo F, Dichtl W, Burgdorf Ch, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Shoji T., Ishibashi I, Takahara M, Himi T, Din J, AlShammari A, Prasad A, Rihal CS, Liu K, Schulze C, Bianco M, Jörg L, Rickl H, Pestana G, Nguyen TH, Böhm M. Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfuß G, Pieske BM, Schunkert H. Borggrefe M, Thiele H, Bauersachs J, Katus HA, Horowitz JD, Di Mario C, Münzel T, Crea F, Bax JJ, Lüscher TF, Ruschitzka F, Ghadri JR, Opolski G, Templin C. Age-Related Variations in Takotsubo Syndrome. J. Am. Coll. Cardiol . 2020; 75(16):1869-1877.

Carlos C, Johnson TW, Sigmund S, Buszman PP, Poerner TC, Francesco L, Borja I, Yongcheol K, Mischke K, Jaguszewski MJ, Gutiérrez-Chico JL. ISCHEMIA trial: the longawaited evidence to confirm our prejudices. Cardiol. J. 2020 : vol. 27, nr 4, s. 336-341.

Ciurzyński M, Domienik-Karłowicz J, Jaguszewski MJ, Pruszczyk P. COVID-19 and its implication for venous thromboembolism. Cardiol. J. 2020 : vol. 27, nr 5, s. 481-484.

D’Ascenzo F, Gili S, Bertaina M, Iannaccone M, Cammann VL, Di Vece D, Kato K, Saglietto A, Szawan KA, Frangieh AH, Boffini B, Annaratone M, Sarcon A, Levinson RA, Franke J, Napp C. Jaguszewski MJ, Noutsias M, Münzel T, Knorr M, Heiner S, Katus HA, Burgdorf C, Schunkert H, Thiele H, Bauersachs J, Tschöpe C, Pieske BM, Rajan B, Michels G, Pfister R, Cuneo A, Jacobshagen C, Hasenfuß G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KJE, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WF, Empen K, Felix SB, Delmas C, Lairez O, El-Battrawy I, Akin I, Borggrefe M, Horowitz JD, Kozel M, Tousek P, Widimský P, Gilyarova E, Shilova A, Gilyarov M, Biondi-Zoccai G, Winchester DE, Ukena C, Neuhaus M, Bax JJ, Prasad A, Di Mario C, Böhm M, Gasparini M, Ruschitzka F, Bossone E, Citro R, Rinaldi M, De Ferrari GM, Lüscher T, Ghadri JR, Templin C. Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry. Eur. J. Heart Fail. 2020; 22(2):330-337.

Ding KJ, Cammann VL, Szawan KA, Stähli BE, Wischnewsky M, Di Vece D, Citro R, Jaguszewski MJ, Seifert B, Sarcon A, Knorr M, Heiner S, Gili S, D’Ascenzo F, Neuhaus M, Napp LC, Franke J, Noutsias M, Burgdorf C, Koenig W, Kherad B, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Pott A, Meyer P, Arroja JD, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Paolini C, Bilato C, Carrilho-Ferreira P, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, GaliutoL, Dichtl W, Chan C, Bridgman P, Delmas C, Lairez O, El-Battrawy I, Akin I, Gilyarova E, Shilova A, Gilyarov M, Kozel M, Tousek P, Widimský P, Winchester DE, Galuszka J, Ukena C, Horowitz JD, Di MC, Prasad A, Rihal CS, Pinto FJ, Crea F, Borggrefe M, Braun-Dullaeus RC, Rottbauer W, Bauersachs J, Katus HA, Hasenfuβ G, Tschöpe C, Pieske BM, Thiele H, Schunkert H, Böhm M, Felix SB, Münzel T, Bax JJ, Lüscher TF, Ruschitzka F, Ghardi JR, Bossone E, Templin C. Intraventricular thrombus formation and embolism in Takotsubo syndrome : insights from the International Takotsubo Registry. Arterioscler. Thromb. Vasc. Biol. 2020 : vol. 40, nr 1, s. 279-287.

Domienik-Karłowicz J, Jaguszewski MJ, Kurzyna M. Direct oral anticoagulants in cancerassociated venous thromboembolism: It is high time for a change of therapeutic paradigm. Cardiol. J. 2020; 27(4):347-349.

Drozd A, Smereka J, Filipiak KJ, Jaguszewski MJ, Ładny JR, Bielski K, Nadolny J, Ruetzler K, Szarpak Ł. Intraosseous versus intravenous access while wearing personal protective equipment: a meta-analysis in the era of COVID-19. Kardiol. Pol. 2021. doi: 10.33963/KP.15741.

Dzieciatkowski T, Szarpak Ł, Filipiak KJ, Jaguszewski MJ, Ladny JR, Smereka. COVID-19 challenge for modern medicine. Cardiol. J. 2020;27(2):175-183.

Engel LC, Landmesser U, Abdelwahed YS, Jaguszewski MJ, Gigengack K, Wurster TH, Skurk C, Manes C, Schuster A, Noutsias M, Hamm B, Botnar RM, Makowski MR, Bigalke B. Comprehensive multimodality characterization of hemodynamically significant and nonsignificant coronary lesions using invasive and noninvasive measures. PLoS One 2020; 15(1):e0228292.

Gasecka A, Siwik D, Gajewska M, Jaguszewski MJ, Mazurek T, Filipiak KJ, Postuła M, Eyileten C. Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes. J. Clin. Med. 2020 : vol. 9, nr 9, art. ID 2807, s. 1-12.

Gąsecka A, Filipiak KJ, Jaguszewski MJ. Impaired microcirculation function in COVID-19 and implications for potential therapies Cardiol. J. 2020 : vol. 27, nr 5, s. 485-488.

Gąsecka A, Rogula S, Eyileten C, Postuła M, Jaguszewski MJ, Kochman J, Mazurek T, Nieuwland R. Filipiak KJ. Role of P2Y Receptors in Platelet Extracellular Vesicle Release. Int. J. Mol. Sci. 2020; 21(17):6065.

Hellmann M, Piotrowski J, Kaszubowski M, Dudziak M, Anisimowicz L. Invasive Assessment of the Myocardial Microcirculation during Beating Heart Coronary Artery Bypass Grafting. J Clin Med. 2020 Mar 1;9(3):663. doi: 10.3390/jcm9030663.

Huang QF, Aparicio LS, Thijs L, Wei FF, Melgarejo JD, Cheng YB, Sheng CS, Yang WY, Gilis-Malinowska N, Boggia J, Niiranen TJ, Wojciechowska W, Stolarz-Skrzypek K, Barochiner J, Ackermann D, Tikhonoff V, Ponte B, Pruijm M, Casiglia E, Narkiewicz K, Filipovský J, Czarnecka D, Kawecka-Jaszcz K, Jula AM, Bochud M, Vanassche T, Verhamme P, Struijker-Boudier HAJ, Wang JG, Zhang ZY, Li Y, Staessen JA; IDCARS (International Database of Central Arterial Properties for Risk Stratification) Investigators. Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components. Hypertension. 2020 Aug;76(2):350-358. doi: 10.1161/HYPERTENSIONAHA.120.14787.

Ishag A, Szarpak L, Filipiak KJ, Smereka J, Dabrowski M, Ghavami S, Jaguszewski MJ. Interferon lambda with remdesivir as a potential treatment option in COVID-19. Disaster Emerg. Med. J. 2020 : vol. 5, nr 3, s. 174.

Jaguszewski MJ. Odrębność leczenia w kardiologii inwazyjnej. [W:] Koronawirus SARS-CoV-2: zagrożenie dla współczesnego świata / red. nauk. T. Dziewiątkowski, K.J. Filipiak. Warszawa: PZWL Wydawnictwo Lekarskie, 2021. S. 144-149.

Jaguszewski MJ, Szarpak Ł, Filipiak KJ. Impact of COVID-19 pandemic on out-of-hospital cardiac arrest survival rate. Resuscitation 2020; 159:40-41.

Jurgiel J, Filipiak KJ, Szarpak Ł, Jaguszewski MJ, Smereka J, Dzieciątkowski T. Do pets protect their owners in the COVID-19 era? Med. Hypotheses 2020; 142:109831.

Kapłon-Cieślicka A, Kupczyńska K, Dobrowolski P, Michalski B, Jaguszewski MJ, Banasiak W, Burchardt P, Chrzanowski Ł, Darocha S, Domienik-Karłowicz J, Drożdż J, Fijałkowski M, Filipiak K, Gruchała M, Jankowska EA, Jankowski P, Kasprzak JD, Kosmala W, Lipiec P, Mitkowski P, Mizia-Stec K, Szymański P, Tycińska A, Wańha W, Wybraniec M, Witkowski A, Ponikowski P. On the search for the right definition of heart failure with preserved ejection fraction. Cardiol. J. 2020 : vol. 27, nr 5, s. 449-468.

Kowalik MM, Trzonkowski P, Łasińska-Kowara M, Mital A, Smiatacz T, Jaguszewski MJ. COVID-19 : Toward a comprehensive understanding of the disease. Cardiol. J. 2020 : vol. 27, nr 2, s. 99-114.

Kubica J, Adamski P, Niezgoda P, Alexopoulos D, Badariene J, Budaj A, Buszko K, Dudek D, Fabiszak T, Gąsior M, Gil R, Gorog D, Grajek S, Gurbel P, Gruchała M, Jaguszewski MJ, James S, Jeong Y, Jilma B, Kasprzak JD, Kleinrok A, Kubica A, Kuliczkowski W, Legutko J, Lesiak M, Siller-Matula JM, Nadolny K, Pstrągowski K, Di Somma S, Specchia G, Stępińska J, Tantry Udaya S, Tycińska A, Verdoia M, Wojakowski W, Navarese EP. Prolonged antithrombotic therapy in patients after acute coronary syndrome: a critical appraisal of current European Society of Cardiology guidelines. Med. Res. J. 2020 : vol. 5, nr 3, s. 177-190. 52. Ludwin K., Filipiak KJ, Jaguszewski M., Pruc M., Paprocki M., Smereka J., Szarpak ., Dabrowski M., Czekajlo M. Place of prefilled syringes in COVID-19 patient based on current evidence. Am. J. Emerg. Med. 2021; 39:234-235.

Ludwin K, Filipiak KJ, Jaguszewski MJ, Pruc M, Paprocki M, Smereka J, Szarpak Ł, Dabrowski M, Czekajlo M. Systematic review and meta-analysis appraising efficacy and safety of adrenaline for adult cardiopulmonary resuscitation. Cardiol. J. 2020. doi: 10.5603/CJ.a2020.0133

Ludwin K, Safiejko K, Smereka J, Nadolny K, Cyran M, Yakubtsevich R, Jaguszewski MJ, Filipiak KJ, Szarpak Ł, Rodríguez-Núñez A Effect of amiodarone and lidocaine on shock-refractory cardiac arrest: a systematic review and meta-analysis. Kardiol. Pol. 2020 : t. 78, nr 10, s. 999-1007.

Ludwin K, Smereka J, Nadolny K, Ładny JR, Szarpak A, Fajfer Z, Jaguszewski MJ, Filipiak KJ, Szarpak Ł. Cardiopulmonary resuscitation in the prone position: a good option for patients with COVID-19. Anesth. Analg. 2020: vol. 131, nr 3, s. e172-e173.

Ludwin K, Szarpak L, Ruetzler K, Smereka J, Böttiger BW, Jaguszewski MJ, Filipiak KJ. Cardiopulmonary resuscitation in the prone position: a good option for patients with COVID-19. Anesth. Analg. 2020 : vol. 131, nr 3, s. e172-e173.

Łoś A, Hellmann M. Real-time microcirculation imaging during beating-heart coronary artery bypass grafting. Kardiol Pol. 2020 Aug 25;78(7-8):780-781. doi: 10.33963/KP.15322. Epub 2020 Apr 28.

Malysz M, Dabrowski M, Böttiger BW, Smereka J, Kulak K, Szarpak A, Jaguszewski MJ, Filipiak KJ, Ladny JR, Ruetzler K., Szarpak Ł. Resuscitation of the patient with suspected/confirmed COVID-19 when wearing personal protective equipment: A randomized multicenter crossover simulation trial. Cardiol. J. 2020; 27(5):497-506.

Malysz M, Jaguszewski MJ, Szarpak L, Telecka-Gadek D, Bielski K, Dabrowska A, Smereka J, Filipiak KJ Comparison of different chest compression positions for use while wearing CBRN-PPE: a randomized crossover simulation trial. Disaster Emerg. Med. J. 2020: vol. 5, nr 3, s. 127-133.

Małysz M, Smereka J, Jaguszewski MJ, Dąbrowski M, Nadolny K, Ruetzler K, Ładny JR, Sterliński M, Filipiak KJ, Szarpak Ł. An optimal chest compression technique using personal protective equipment during resuscitation in the COVID-19 pandemic: a randomized crossover simulation study. Kardiol. Pol. 2020; 78(12):1254-1261.

Merks P, Drozd M, Świeczkowski D, Białoszewski A, Fehir Sola K, Harezlak T, Chmielewska-Ignatowicz T, Jaguszewski MJ. A comparison of patient attitudes towards community pharmacies in Poland and in England. Acta Pol. Pharm. – Drug Res. 2020 : vol. 77, nr 5, s. 805-813

Merks P, Jakubowska M, Drelich E, Świeczkowski D, Bogusz J, Bilmin K, Fehir SK, May A, Majchrowska A, Koziol M, Pawlikowski J, Jaguszewski MJ, Vaillancourt R. The legal extension of the role of pharmacists in light of the COVID-19 global pandemic. Res. Soc. Adm. Pharm. 2021 : vol. 17, nr 1, s. 1807-1812.

Merks P., Religioni U., Arciszewska K., Pankiewicz W., Jaguszewski M., Vaillancourt R. “Usability testing and satisfaction of “The Patient Access: A mobile health application for patients with venous thromboembolic disease. A pilot study. Cardiol. J. 2020. doi: 10.5603/CJ.a2020.0107.

Merks P, Świeczkowski D, Zerhau M, Gawronska A, Kowalczuk A, Gajewski K, Däinghaus R, Jaguszewski MJ, Brindley D. Pilot implementation of falsified medicines directive in hospital pharmacy to develop best practices for medicine decommissioning process. Pharmacy 2020 : vol. 8, nr 1, art. ID 34, s. 1-6.

Mickiewicz A, Futema M, Ćwiklińska A, Kuchta A, Jankowski M, Kaszubowski M, Chmara M, Wasąg B, Fijałkowski M, Jaguszewski MJ, Higher responsiveness to rosuvastatin in polygenic versus monogenic hypercholesterolemia: a propensity score analysis. Life (Basel) 2020 : vol. 10, nr 5, art ID 73, s. 1-14.

Napp LC, Cammann VL, Jaguszewski MJ, Szawan KA, Wischnewsky M, Gili S, Knorr M, Heiner S, Citro R, Bossone E, D’Ascenzo F, Neuhaus M, Franke J, Sorici-Barb I, Noutsias M, Burgdorf C, Koenig W, Kherad B, Sarcon A, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Pott A, Meyer P, Arroja JD, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Hauck C, Paolini C, Bilato C, Imori Y, Kato K, Kobayashi Y, Opolski G, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Dichtl W, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, El-Battrawy I, Akin I, Gilyarova E, Shilova A, Gilyarov M, Horowitz JD, Polednikova K, Tousek P, Widimský P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Di Mario C, Prasad A, Rihal CS, Schulze PC, Bianco M, Crea F, Borggrefe M, Maier LS, Pinto FJ, Braun-Dullaeus RC, Rottbauer W, Katus HA, Hasenfuß G, Tschöpe C, Pieske BM, Thiele H, Schunkert H, Böhm M, Felix SB, Münzel T, Bax JJ, Bauersachs J, Braunwald E, Lüscher TF, Ruschitzka F, Ghadri JR, Templin C. Coexistence and outcome of coronary artery disease in Takotsubo syndrome. Eur. Heart J. 2020 : vol. 41, nr 34, s. 3255-3267.

Pajkowski M, Chlebus K, Hellmann M. Microvascular endothelial dysfunction in a young patient with familial hypercholesterolemia. Pol Arch Intern Med. 2020 Aug 27;130(7-8):679-680. doi: 10.20452/pamw.15411.

Piotrowski J, Anisimowicz L, Hellmann M. Laser Doppler flowmetry to assess myocardial microcirculation. Cardiol J. 2020 Feb 27. doi: 10.5603/CJ.a2020.0025.

Pruc M, Smereka J, Dzieciatkowski T, Jaguszewski MJ, Filipiak KJ, Szarpak Ł. Kawasaki disease shock syndrome or toxic shock syndrome in children and the relationship with COVID-19. Med Hypotheses. 2020; 144:109986.

Robak O, Dudek M, Ladny JR, Szarpak L, Gilis-Malinowska N, Frass M. Cardiac tamponade as a cause of COVID-19. Cardiol J. 2020;27(6):900-901. doi: 10.5603/CJ.2020.0175.

Safiejko K, Smereka J, Filipiak K, Szarpak A, Dabrowski M, Ladny JR, Jaguszewski MJ, Szarpak Ł. Effectiveness and safety of hypotension fluid resuscitation in traumatic hemorrhagic shock: a systematic review and meta-analysis of randomized controlled trials. Cardiol. J. 2020. doi: 10.5603/CJ.a2020.0096.

Safiejko K, Smereka J, Pruc M, Ladny JR, Jaguszewski MJ, Filipiak KJ, Yakubtsevich R, Szarpak Ł. Efficacy and safety of hypertonic saline solutions fluid resuscitation on hypovolemic shock: A systematic review and meta-analysis of randomized controlled trials. Cardiol. J . 2020. doi: 10.5603/CJ.a2020.0134.

Smereka J, Puslecki M, Ruetzler K, Filipiak KJ, Jaguszewski MJ, Ladny JR, Szarpak L. Extracorporeal membrane oxygenation in COVID-19. Cardiol. J. 2020 : vol. 27, nr 2, s. 216-217.

Smereka J, Ruetzler K, Szarpak L, Filipiak KJ, Jaguszewski MJ, Role of mask/respirator protection against SARS-CoV-2. Anesth. Analg. 2020 : vol. 131, nr 1, s. e33-e34.

Smereka J, Szarpak Ł, Filipiak KJ, Jaguszewski MJ, Ladny JR. Which intravascular access should we use in patients with suspected/confirmed COVID-19? Resuscitation 2020;151:8-9.

Stańska A, Fijałkowska J, Targoński R, Fijałkowski M, Jaguszewski MJ, Rogowski J, Szurowska E, Jagielak D. Transcatheter aortic valve implantation through a transcarotid approach and cerebral injury. Kardiol. Pol. 2020 : t. 78, nr 7-8, s. 756-758.

Szarpak L, Filipiak KJ, Mosteller L, Jaguszewski MJ, Smereka J, Ruetzler K, Sanchit A, Ladny JR. Survival, neurological and safety outcomes after out of hospital cardiac arrests treated by using prehospital therapeutic hypothermia: A systematic review and meta-analysis. Am. J. Emerg. Med. 2020; 10.1016/j.ajem.2020.02.019.

Szarpak L, Ruetzler K, Dabrowski M, Nadolny K, Ladny JR, Smereka J, Jaguszewski MJ, Filipiak KJ. Dilemmas in resuscitation of COVID-19 patients based on current evidence. Cardiol. J. 2020 : vol. 27, nr 3, s. 327-328.

Szarpak L, Ruetzler K, Safiejko K, Hampel M, Pruc M, Kanczuga-Koda L, Filipiak KJ, Jaguszewski MJ. Lactate dehydrogenase level as a COVID-19 severity marker. Am. J. Emerg. Med. 2020; doi: 10.1016/j.ajem.2020.11.025.

Szarpak L, Smereka J, Filipiak KJ, Ladny JR, Jaguszewski MJ. Cloth masks versus medical masks for COVID-19 protection. Cardiol. J. 2020 : vol. 27, nr 2, s. 218-219.

Szarpak Ł, Dzieciątkowski T, Jaguszewski MJ. Is remdesivir important in clinical practice as a treatment against COVID-19? A study based on meta-analysis data. Pol. Arch. Intern. Med. 2020. DOI: 10.20452/pamw.15686.

Szarpak Ł, Filipiak KJ, Gasecka A, Pruc M, Drozd A, Jaguszewski MJ. Correlation between takotsubo cardiomyopathy and SARS-CoV-2 infection. Med Hypotheses. 2020; 146:110454.

Szarpak Ł, Nowak B, Kosior D, Zaczynski A, Filipiak, KJ, Jaguszewski MJ. Cytokines as a predictor of COVID-19 severity: evidence from meta-analysis. Pol. Arch. Intern. Med. 2020. DOI: 10.20452/pamw.15685.

Szarpak Ł, Zaczynski A, Kosior D, Bialka S, Ladny JR, Gilis-Malinowska N, Smereka J, Kanczuga-Koda L, Gasecka A, Filipiak KJ, Jaguszewski MJ. Evidence of diagnostic value of ferritin in patients with COVID-19. Cardiol. J. 2020. doi: 10.5603/CJ.a2020.0171

Świeczkowski D, Zdanowski S, Merks P, Szarpak Ł, Vaillancourt R, Jaguszewski MJ. The plague of unexpected drug recalls and the pandemic of falsified medications in cardiovascular medicine as a threat to patient safety and global public health: A brief review. Cardiol. J. 2020. doi: 10.5603/CJ.a2020.0168

Świeczkowski D, Merks P, Jaguszewski MJ. The safe use of drugs on the example of qualitative analysis of opinions of Internet users about drugs containing the recalled valsartan – an exploratory study. J. Health Policy Outcomes Res. 2020, nr 1, s. 1-9.

Narożny A, Zdanowski S, Świeczkowski D, Jaguszewski MJ, Krysiński J, Merks P. Ocena poziomu satysfakcji pacjentów z etykietopiktogramów w aptece pilotażowej. Farm. Pol. 2020 : vol. 76, nr 4, s. 185-194.

Wańha W, Mielczarek M, Gilis-Malinowska N, Roleder T, Milewski M, Ładziński S, Ciećwierz D, Gąsior P, Pawłowski T, Januszek R, Kowalówka A, Kolodziejczak M, Bartuś S, Gruchała M, Smolka G, Navarese EP, Dudek D, Ochała A, Kedhi E, Jaguszewski MJ, Wojakowski W. Safety and Efficacy of Embolic Protection Devices in Saphenous Vein Graft Interventions: A Propensity Score Analysis-Multicenter SVG PCI PROTECTA Study. J. Clin. Med. 2020; 9(4):1198.

Wilkowski M, Lewicki Ł, Olszewski R, Priebe A, Jaguszewski MJ, Szołkiewicz M. First-inhuman radiofrequency ablation of ventricular tachycardia performed through an Atrial Flow Regulator device. Cardiol. J. 2020. doi: 10.5603/CJ.a2020.0172.

Wozniak-Mielczarek L, Sabiniewicz R, Nowak R, Gilis-Malinowska N, Osowicka M, Mielczarek M. New Screening Tool for Aortic Root Dilation in Children with Marfan Syndrome and Marfan-Like Disorders. Pediatr Cardiol. 2020 Mar;41(3):632-641. doi: 10.1007/s00246-02002307-0. Epub 2020 Jan 31.

Ćwiklińska A, Wieczorek E, Gliwińska A, Marcinkowska M, Czaplińska M, Mickiewicz A, Kuchta A, Kortas-Stempak B, Gruchała M, Dębska-Ślizień A, Król E, Jankowski M. Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation. Clin Chem Lab Med. 2020 Dec 24;59(5):857-867. doi: 10.1515/cclm-2020-1366. PMID: 33554544.

Hennig M, Brandt-Varma A, Wołoszyn-Durkiewicz A, Bautembach-Minkowska J, Buraczewska M, Świętoń D, Mickiewicz A, Rynkiewicz A, Gruchała M, Limon J, Wasąg B, Chmara M, Walczak M, Myśliwiec M. Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland. Life (Basel). 2020 Nov 4;10(11):270. doi: 10.3390/life10110270. PMID: 33158089; PMCID: PMC7694222.

Mickiewicz A, Kreft E, Kuchta A, Wieczorek E, Marlęga J, Ćwiklińska A, Paprzycka M, Gruchała M, Fijałkowski M, Jankowski M. The Impact of Lipoprotein Apheresis on Oxidative Stress Biomarkers and High-Density Lipoprotein Subfractions. Oxid Med Cell Longev. 2020 Aug 5;2020:9709542. doi: 10.1155/2020/9709542. PMID: 32832012; PMCID: PMC7428943.

Kanikowska D, Korybalska K, Mickiewicz A, Rutkowski R, Kuchta A, Sato M, Kreft E, Fijałkowski M, Gruchała M, Jankowski M, Bręborowicz A, Witowski J. Flaxseed (Linum Usitatissimum L.) Supplementation in Patients Undergoing Lipoprotein Apheresis for Severe Hyperlipidemia-A Pilot Study. Nutrients. 2020 Apr 18;12(4):1137. doi: 10.3390/nu12041137. PMID: 32325781; PMCID: PMC7231079.


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