"Functional mapping of cancer to optimise diagnostics for lung and breast cancer" – open lecture
19.01.2024
An open lecture entitled Functional mapping of cancer to optimise diagnostics for lung and breast cancer, by Uppsala University specialists Prof. Patric Micke and Prof. Catrina Strell will take place on 30 January at 2 p.m. in seminar room 3/DD/03 in the CMI building.
The event will be hosted by Prof. Rafał Dziadziuszko, Head of the Department of Oncology & Radiotherapy of the MUG and Bartosz Sobocki, M.D., a doctoral student from the same unit and winner of the IDUB Research Travel Grant program, who is carrying out a study with Prof. Micke and Prof. Strell (partly at Uppsala University).
The topics of the lecture are part of the activities of IDUB PRA 1, which is led by Prof. Jacek Jassem from the Department of Oncology and Radiotherapy of the MUG.
Speakers’ profiles
Patric Micke, M.D., Ph.D., is a distinguished Professor in Translational Pathology at the Department of Immunology, Genetics, and Pathology, Uppsala University and holds a shared position as a Clinical Pathologist (30%). He leads the “Integrative Lung Cancer Pathology” group aiming to unrevail tumorigenic mechanisms in lung cancer. His medical education started as a resident in medical oncology at the University Hospital in Mainz, Germany, where he was responsible for the out-patient clinic for lung cancer patients. During his post-doctoral tenure at the Ludwig Institute for Cancer Research in Uppsala and the Department of Pathology and Oncology at the Karolinska Institute, he recognized the role of patients’ tissue in deciphering the tumorigenic mechanisms in its in situ enviroment. Dr. Micke’s subsequent education as a pathologist provided him with a unique opportunity to bridge translational cancer research with clinical practice.
In response to evolving trends in cancer treatment, Dr. Micke conducted important studies that directly addressed the changing landscape of clinical pathology. The breaktrough of immunotherapy are connected to his research efforts, particularly focusing on the tumor stroma, comprising genetically normal cells such as fibroblasts, vascular cells, and immune cells—all crucial players in tumorigenesis. His meticulous studies of the mesenchymal cancer compartment yielded detailed tissue maps, offering insights into individual immune phenotypes with direct clinical implications. Simultaneously, as a consultant pathologist and cancer researcher, Dr. Micke contributed in optimizing diagnostic algorithms, thereby influencing the diagnostic workflow for lung cancer patients in Sweden.
Dr. Micke’s publication record includes 156 original research articles, with 47 as first or senior author. His work has garnered over 10 000 citations, reflecting a significant contribution to the scientific community, underscored by an impressive H-index of 47.
Catrina Strell, Ph.D., obtained her Ph.D. in biochemistry in Germany, followed by a postdoc time at the Karolinska Institute in Stockholm, Sweden, where she worked on the characterization of fibroblasts in ductal carcinoma in situ (DCIS). Thereafter Carina Strell worked as a researcher at the Science for Life Laboratory, also in Stockholm, where she got introduced into advanced spatial omics techniques for tissue analysis. Carina Strell joined the research group of Prof. Patrick Micke at Uppsala University in 2019, where she established her own research line on early breast cancer. Today, Carina Strell and Patrick Micke are leading a joint research group at Uppsala University, with special emphasis on the application of spatial tissue analyses on breast and lung cancer. Carina Strell also is PI of a small research team on early breast cancer at Bergen University in Norway funded by the Trond Mohn Foundation.
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