Publication on the mechanisms of DNA repair

14.09.2023

Bartłomiej Tomasik, Ph.D. from the Department of Oncology & Radiotherapy of the Medical University of Gdańsk, is co-author of an article entitled Dynamics of the DYNLL1–MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs published in the journal Nature Structural & Molecular Biology (IF=18,361). The paper describes a hitherto unknown mechanism of double-strand break repair in DNA involving the proteins DYNLL1, MRE11, and the protein complex Shieldin. The researchers note that the described mechanism may play an important role in patients treated with PARP (poly(ADP-ribose) polymerase) inhibitors.

– The article was written in collaboration with researchers from Prof Dipanjan Chowdhury’s team at Harvard Medical School and Dana-Farber Cancer Institute. I worked in the Professor’s team from 2020 to 2021 as part of a postdoctoral fellowship carried out thanks to, among other things, the support of the National Academic Exchange Agency and the Prof. Walczak programme – explains Bartłomiej Tomasik, Ph.D.. – My role in the above-mentioned work was primarily to produce stable cell lines based on the CRISPR/Cas9 technique, which allows for selective genome editing.

A scientist from our University is the coordinator of the IDUB Research Team dealing with the biological and physical aspects of ionising radiation and their translation into clinical practice. The group is actively seeking partners for further scientific activities. Those interested in cooperation can obtain detailed information by email by contacting Bartlomiej Tomasik, Ph.D. bartlomiej.tomasik@gumed.edu.pl.

photo Paweł Sudara/MUG