Subject Area and Research Team: VII. Physical and clinical aspects of radiotherapy
Research topics
1. Biology
– Impact of total body radiotherapy (TBI) on regulatory T-cells
– biomarkers in biodosimetry
– DNA double-strand breaks repair mechanisms
– mitosis regulation
– molecular basis of radiotherapy-induced cardiac conduction reprogramming
– novel prognostic and predictive molecular signatures in non-small-cell lung cancer
2. Physical aspects
– Verification of absorbed dose and patient position during breath hold radiotherapy (RT)
– In vivo dosimetry during TBI
– Dose distribution of brachytherapy in advanced cervical cancer
– radiotherapy-induced lymphopenia prediction
3. Clinical aspects
– Long-term results of RT in locally advanced and oligometastatic non-small cell lung cancer
– Long-term results of concurrent radiochemotherapy in head and neck cancer
– Prevention and treatment of RT-induced osteonecrosis of the jaw
– Radiological and radiomics features of oropharyngeal cancers with nodal metastases
– Esophagus sparing RT techniques in non-small cell lung cancer
– Reduction of RT dose to the heart in breast cancer patients
– Impact of stereotactic RT on lung parenchyma
– radiosurgery in the treatment of ventricular tachycardia
Coordinators
| Coordinator #1 | Coordinator #2 | Coordinator #3 | |
|---|---|---|---|
| Name and surname |  |
 |
 |
| Academic degree | Dr. Habil. | Ph.D. Eng. | Ph.D. |
| Employment unit | Department of Oncology and Radiotherapy | Department of Oncology and Radiotherapy Faculty of Mathematics, Physics and Computer Science, Institute of Experimental Physics, Department of Acoustics and Nuclear Physics – University Of Gdańsk |
Department of Oncology & Radiotherapy |
| Polish Platform of Medical Research | Dr. Habil. Andrzej Badzio | Joanna Kamińska, Ph.D. Eng. | Bartłomiej Tomasik, Ph.D. |
| abadzio@gumed.edu.pl | j.kaminska@gumed.edu.pl | bartlomiej.tomasik@gumed.edu.pl | |
| Phone number | +48 58 349 45 10 | +48 58 349 22 81 | +48 58 349 45 10 |
Research Team: VII. Physical and clinical aspects of radiotherapy
Team Members: VII. Physical and clinical aspects of radiotherapy (166 KB)Our research group offers irradiation services for cells and tissues – for detailed information, please contact Bartłomiej Tomasik or Joanna Kamińska.
Feel free to contact one of our coordinators to join our Research Team.
Key current projects
1. Impact of low dose total body radiotherapy on Treg function
2. EPR dosimetry in deep-inspiration breath hold radiotherapy
3. Contralateral oesophagus sparing technique and predictive models for radiation-induced esophagitis in non-small cell lung cancer patients receiving concurrent chemoradiotherapy.
4. Radiological and radiomics features of oropharyngeal cancers with nodal metastases
5. Reduction of the dose to left coronary vessel and heart in proton irradiation and photon deep breath hold radiotherapy in breast cancer patients
6. Lymphocyte-sparing radiotherapy – novel tools to predict lymphocyte depletion loss
7. Digital biopsy – predicting the PD‐L1 status from radiomics features of [18F]FDG PET/CT
8. Molecular basis of radiotherapy-induced cardiac conduction changes
9. Radiomics-based prediction of interstitial lung disease and pneumonitis after chemoradiotherapy and immunotherapy in non-small-cell lung cancer
International cooperation
| Foreign partner (unit name) | Principal investigator(s) | Area of cooperation | |
|---|---|---|---|
| 1. | Laboratory of Pathology, National Cancer Institute (NCI), Bethesda, Maryland, USA | Jerzy Lasota | Clinical aspects of radiotherapy – outcome of treatment and side effects of radiotherapy |
| 2. | Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy | Barbara Alicja Jereczek-Fossa | Clinical aspects of radiotherapy – outcome of treatment and side effects of radiotherapy |
| 3. | Division of Radiation and Genome Stability, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA | Dipanjan Chowdhury, Alexander Spektor | biomarkers in biodosimetry, DNA double-strand breaks repair mechanism, mitosis regulation |
| 4. | Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA | Harald Paganetti | radiotherapy-induced lymphopenia prediction |
| 5. | Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands | Martin Fast | radiosurgery in the treatment of ventricular tachycardia |
| 6. | Department of Cardiology, Heart Lung Centre, Leiden University Medical Centre, Leiden, the Netherlands | Katja Zeppenfeld | molecular basis of radiotherapy-induced cardiac conduction reprogramming |
| 7. | Department of Radiation Oncology, University Medical Center Schleswig-Holstein, Kiel, Germany | Oliver Blanck | radiosurgery in the treatment of ventricular tachycardia |
| 8. | Department of Oncology, Aarhus University Hospital, Aarhus, Denmark | Stine Sofia Korreman | molecular basis of radiotherapy-induced cardiac conduction reprogramming |
| 9. | Department of Immunology, Genetics, and Pathology, Uppsala University, Sweden | Carina Strell, Patrick Micke | novel prognostic and predictive molecular signatures in non-small-cell lung cancer |
| 10. | Department of Oncology, University Hospital Ostrava, Ostrava, Czechia | Pavel Dvorak | molecular basis of radiotherapy-induced cardiac conduction reprogramming |
Key publications
1. Christodoulou M, Blackhall F, Mistry H, Leylek A, Knegjens, Remouchamps V, Martel-Lafay Farré N, Zwitter M ,Lerouge D, Pourel N, Janicot H, Scherpereel A, Tissing-Tan C, Peignaux K, Geets X, Konopa K , Faivre-Finn C. Compliance and Outcome of Elderly Patients Treated in the Concurrent Once-Daily Versus Twice-Daily Radiotherapy (CONVERT) Trial. J Thorac Oncol 2019; vol. 14: p. 63-71.
2. Zheng X-F, Sarkar A, Lotana H, Syed A, Nguyen H, Ivey R G, Kennedy J J, Whiteaker J R, Tomasik B, Huang K, Li F, D’Andrea A D, Paulovich A G, Shah K, Spektor A, Chowdhury D. CDK5-cyclin B1 regulates mitotic fidelity. Nature. 2024 Sep;633(8031):932-940.
3. Swift M L, Zhou R, Syed A, Moreau L A, Tomasik B, Tainer J A, Konstantinopoulos P A, D’Andrea A D, He Y J & Chowdhury D. Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. Nat Struct Mol Biol. 2023 Oct;30(10):1456-1467.
4. Grehn M, Mandija S, Miszczyk M, Krug D,Tomasik B, Stickney K E, Alcantara P, Alongi F, Anselmino M, Salgado Aranda R, Balgobind B V, Boda-Heggemann J, Boldt L-H, Bottoni N, Cvek J, Elicin O, De Ferrari G M, Hassink R J, Colien Hazelaar, Hindricks G, Hurkmans C, Lotti C, Jadczyk T, Jiravsky O, Jumeau R, Kristiansen S B, Levis M, López M A, Martí-Almor J, Mehrhof F, Møller D S, Molon G, Ouss A, Peichl P, Plasek J, Postema P G, Quesada A, Reichlin T, Rordorf R, Rudic B, Saguner A M, Ter Bekke R M A, Torrecilla J L, Troost E G C, Vitolo V, Andratschke N, Zeppenfeld K, Blamek S, Fast M, de Panfilis L, Blanck O, Pruvot E, Verhoeff J J C. STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe. EP Europace 2023.
5. Nowak J, Pawłowska E. Technical note: an algorithm and software for conversion of radiotherapy contour-sequence data to ready-to-print 3D structures. Med. Phys. 2019; vol. 46(4): p. 1829-1832.
6. Zemanova M, Jakopovic M, Stanic K, Łazar-Poniatowska M, Vrankar M, Rusu P, Ciuleanu T, Radosavljevic D, Bogos K, Nawrocki S. Treatment patterns and real-world evidence for stage III non-small cell lung cancer in Central and Eastern Europe. Radiol Oncol 2020; vol. 54(4): p. 447-454.