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Laboratory of Thermoanalytical and Spectroscopic Research

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Laboratory of Thermoanalytical and Spectroscopic Research

Department of Analytical Chemistry

Faculty of Pharmacy

Medical University of Gdańsk


ABOUT US

The Laboratory of Thermoanalytical and Spectroscopic Research at the Department of Analytical Chemistry is a core facility laboratory that was established under the “Excellence Initiative – Research University” program at the Medical University of Gdansk. Our unit specializes in testing active pharmaceutical ingredients (APIs) and other raw materials and medicinal products using thermoanalytical and spectroscopic techniques. In addition, the Laboratory can offer substantive support and consultation opportunities for ongoing research and development projects, dedicated to employees, doctoral students at MUG and external entities.


OUR EQUIPMENT POTENTIAL

  • Differential scanning calorimeter, Mettler ToledoDSC822e
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  • FT-IR spectrometer, Nicolet 380-FT-IR, Thermo Fischer Scientific
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  • Raman spectrometer, DXR Smart Raman Thermo Scientific, Thermo Fischer Scientific
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  • Raman spectrometer, DXR Smart Raman Thermo Scientific, Thermo Fischer Scientific


  • Auxiliary equipment:
    Analytical scales, Mettler Toledo XA 105 Dual Range
    Tablet press machine, SPECAC
    Kamush LP400SMd laboratory stirrer

SCOPE OF TESTING

Application of thermoanalytical methods in pharmaceutical analysis and technology, and application of infrared spectroscopic methods (FTIR and Raman spectroscopy) in the analysis of raw materials and medicinal products, more specifically:

  • study of phase transformations
  • study of crystalline substances
  • eutectic detection
  • research related to the occurrence of polymorphism
  • identification of amorphous phases
  • detection of abnormalities
  • determination of solid dispersion system compositions
  • detection of hydrates and solvates.


PUBLICATIONS

Publications that have been developed by using the research methods described:

1. Rojek B., Gazda M., Plenis A., FTIR, Raman spectroscopy and HT-XRD in compatibility study between naproxen and excipients. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023, 302, 123048. https://doi.org/10.1016/j.saa.2023.123048

2. Rojek B., Wesołowski M., A combined differential scanning calorimetry and thermogravimetry approach for the effective assessment of drug substance-excipient compatibility. J Therm Anal Calorim 2023, 148, 845–858. https://doi.org/10.1007/s10973-022-11849-9.

3. Leyk E., Wesolowski M., The effect of cellulose derivatives on paracetamol crystallinity reduction. J Therm Anal Calorim 2022, 147, 10037–10048. https://doi.org/10.1007/s10973-022-11312-9.

4. Rojek B., Gazda M. Wesołowski M., Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis. AAPS PharmSciTech, 2022, 23, 3. https://doi.org/10.1208/s12249-021-02143-2.

5. Lech A., Garbacz P., Sikorski A., Gazda M., Wesołowski M., New Saccharin Salt of Chlordiazepoxide: Structural and Physicochemical Examination. Int J Mol Sci. 2022, 23(19), 12050. doi: 10.3390/ijms231912050.

6. Leyk E., Wesołowski M., Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose. Pharmaceutics 2021, 13, 1836. https://doi.org/10.3390/pharmaceutics13111836.

7. Rojek B., Wesołowski M., Compatibility study of theophylline with excipients using thermogravimetry supported by kinetic analysis. J Therm Anal Calorim, 2021, 143, 227–236. https://doi.org/10.1007/s10973-019-09235-z.

8. Garbacz P., Wesołowski M., Benzodiazepines co-crystals screening using FTIR and Raman spectroscopy supported by differential scanning calorimetry. Spectrochim Acta A Mol Biomol Spectrosc.2020, 234, 118242. doi: 10.1016/j.saa.2020.118242.

9. Garbacz P., Paukszta D., Sikorski A., Wesołowski M., Structural characterization of co-crystals of chlordiazepoxide with p-aminobenzoic acid and lorazepam with nicotinamide by DSC, X-ray diffraction, FTIR and Raman spectroscopy. Pharmaceutics, 2020, 12, 648.

10. Rojek B., Wesołowski M., DSC supported by factor analysis as a reliable tool for compatibility study in pharmaceutical mixtures. J Therm Anal Calorim 2019, 138, 4531–4539. https://doi.org/10.1007/s10973-019-08223-7.

11. Rojek B, Wesołowski M., FTIR and TG analyses coupled with factor analysis in a compatibility study of acetazolamide with excipients. Spectrochim Acta A Mol Biomol Spectrosc. 2019, 208, 285-293. doi: 10.1016/j.saa.2018.10.020.

12. Leyk E, Wesołowski M., Interactions Between Paracetamol and Hypromellose in the Solid State. Front Pharmacol. 2019, 10, 14. doi: 10.3389/fphar.2019.00014.

13. Rojek B., Suchacz B., Wesołowski M., Artificial neural networks as a supporting tool for compatibility study based on thermogravimetric data. Thermochimica Acta, 2018, 659, 222-231.

14. Saganowska P., Wesołowski M., DSC as a screening tool for rapid co-crystal detection in binary mixtures of benzodiazepines with co-formers. J. Therm. Anal. Calorim. 2018, 133, 785-795.

15. Garbacz, P., Wesołowski, M., DSC, FTIR and Raman Spectroscopy Coupled with Multivariate Analysis in a Study of Co-Crystals of Pharmaceutical Interest. Molecules 2018, 23, 2136. https://doi.org/10.3390/molecules23092136

PRICE LIST

The laboratory will perform analyses according to individual orders with adaptation to specific needs of contractors. The cost of the service is priced individually.


CONTACT

Edyta Leyk, Ph.D.

Department of Analytical Chemistry
Medical University of Gdańsk
al. Gen. J. Hallera 107
80-416 Gdańsk

Phone +48 349 15 26
Mail edyta.leyk@gumed.edu.pl

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