Subject Area and Research Team: X. Molecular and biochemical methods for...

Subject Area and Research Team: X. Molecular and biochemical methods for study mechanisms of civilization diseases



Research topics

1. The molecular mechanisms determining cell fate during stress responses and their connection to human pathologies including the role of microRNA in cellular signalling networks

2. The development of RNAi therapies

3. Biomarkers in patients with diabetes and chronic vascular complications

4. Short-Chain Fatty Acids (SCFAs) as potential risk factors for metabolic syndrome and coronary artery disease

5. The role of nucleotide and adenosine metabolism in the pathophysiology of cancer and cardiovascular diseases; adenosine deaminase as a marker of endothelial dysfunction

6. Nucleoside transport inhibitors and ADA inhibitors in endothelial dysfunction therapy


Coordinators

Coordinator #1 Coordinator #2 Coordinator #3
Name and surname
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Rafał Bartoszewski
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Katarzyna Zorena
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Barbara Kutryb-Zając
Academic degree Prof. Dr. Habil. Prof. Dr. Habil. Dr. Habil.
Employment unit Department of Biology and Pharmaceutical Botany Department of Immunobiology and Environmental Microbiology Department of Biochemistry
Polish Platform of Medical Research Prof. Dr. Habil. Rafał Bartoszewski Prof. Dr. Habil. Katarzyna Zorena Dr. Habil. Barbara Kutryb-Zając
Email rafal.bartoszewski@gumed.edu.pl katarzyna.zorena@gumed.edu.pl barbara.kutryb-zajac@gumed.edu.pl
Phone number +48 58 523 12 99 +48 58 349 17 66 +48 58 349 14 60


Research Team X. Molecular and biochemical methods for study mechanisms of civilization diseases

Team Members X. Molecular and biochemical methods for study mechanisms of civilization diseases (176 KB)


Feel free to contact one of our coordinators to join our Research Team.

Key current projects

1. The role and mechanism of signal passing from HIFs 1 to 2 and 3 in human endothelium

2. The molecular mechanisms determining cell fate during UPR

3. The detection microbial metabolites short chain fatty acids in fecal and serum samples

4. The role of adenosine in calcific aortic valve disease and atherosclerosis

Key grants

Funding agency/grant number Title of the project Years
1. NCN (OPUS 19)/2020/37/B/NZ3/00861 Deciding the cell fate during UPR – are we barking up the wrong tree? 2021-2025
2. NCN (SONATA BIS 5)/2015/18/E/NZ3/00687 Molecular mechanisms of HIF switch in human endothelium 2016-2022
3. NCBiR New anticancer compounds interfering function of telomeres 2015-2022
4. NCN/2018/31/N/NZ9/0174 Analysis of transcriptomic and physiological changes in leaves of Brassica napus L. after the exposure to heavy metals, with particular emphasis on the application of sewage sludge on degraded soils 2015-2022
5. The Ministry for Europe and Foreign Affairs (Ministère de l’Europe et des Affaires étrangères), France Optimization of metal phytoextraction using advanced toxicological methods 2018-2020
6. NCN (SONATA 15)/2019/35/D/NZ3/03512 Ecto-enzymes in interactions of vascular endothelium with blood circulating cells in physiology, pathology and therapy; could cells exchange their ecto-enzymes? 2020-2023
7. NAWA (Polonium) BPN/BFR/2021/1/00027/U/00001 Sewage sludge as agricultural fertilizer – green opportunity or hidden threat? Study on the potential spread of antibiotic resistance through long-term land supplementation with sewage sludge 2022-2022

International cooperation

Foreign partner (unit name) Principal investigator(s) Area of cooperation
1. Departments: of Cell, Developmental and Integrative Biology and of Genetic, University of Alabama at Birmingham, Birmingham, USA James Collawn
David K. Crossman
Cell biology
NGS- focused bioinformatics
2. University of Lille, Sciences and Technologies
Department of Biology, Laboratory of Environment, Ecology and Ecotoxicology, Villenueve d’Ascq, France
Franck Vandenbulcke Ecotoxicology
Molecular biology including NGS and bioinformatics
Field work/greenhouse experiments
3. Université de Pau et des Pays de L’Adour, E2S UPPA, CNRS, UMR IPREM 5254, Environmental Microbiology, Pau, France Rémy Guyoneaud Environmental microbiology – NGS, bioinformatics
4. Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria Jolanta Siller-Matula Thrombosis
5. University of Pavia Medical School, Pavia, Italy Stefano De Servi Inflammation and thrombosis
6. Department of Biology, University of Pisa, Italy Roberto Giovannoni Cell biology, immunofluorescence, tracking proteins

National cooperation

Foreign partner (unit name) Principal investigator(s) Area of cooperation
7. Metabolomics Laboratory Clinical Research Centre, Medical University of Bialystok, Poland Michal Ciborowski Metabolomics
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Key publications

1. Bartoszewska S, Cabaj A, Dabrowski M, Collawn JF, Bartoszewski R. miR-34c-5p modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response. Faseb J. 2019; 33: 11541-11554.

2. Bartoszewska S, Kochan K, Piotrowski A, Kamysz W, Ochocka RJ, Collawn JF, Bartoszewski R. The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1 alpha expression in human endothelial cells through a negative feedback loop. Faseb J. 2015: 29: 1467-1479.

3. Bartoszewski R, Moszynska, A, Serocki M, Cabaj A, Polten A, Ochocka R, Dell’Italia L, Bartoszewska S, Kroliczewski J, Dabrowski MD, Collawn JF. Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia. Faseb J. 2019; 33: 7929-7941.

4. Zorena K, Jachimowicz-Duda O, Wąż P. The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications. Biomarkers. 2016; 21(3): 276-82.

5. Koziński M, Ostrowska M, Adamski P, Sikora J, Sikora A, Karczmarska-Wódzka A, Marszałł MP, Boinska J, Laskowska E, Obońska E, Fabiszak T, Kubica J. Which platelet function test best reflects the in vivo plasma concentrations of ticagrelor and its active metabolite? The HARMONIC study. Thromb Haemost. 2016; 116(6): 1140-1149.

6. Iannopollo G, Ferlini M, Koziński M, Ormezzano MF, Crimi G, Lanfranchi L, Camporotondo R, Visconti LO, De Ferrari GM, De Servi S. Patient Outcomes With STEMI Caused by Aneurysmal Coronary Artery Disease and Treated With Primary PCI. J Am CollCardiol. 2017; 69(24): 3006-3007.

7. Jaskulak M, Grobelak A, Vandenbulcke F. Effects of sewage sludge supplementation on heavy metal accumulation and the expression of ABC transporters in Sinapis alba L. during assisted phytoremediation of contaminated sites. Ecotoxicology and Environmental Safety. 2020; 197: 110606.

8. Kutryb-Zajac B, Harasim G, jedrzejewska A, Krol O, Braczko A, Jablonska P, Mierzejewska P, Zielinski J, Slominska EM, Smolenski RT. Macrophage-derived adenosine deaminase 2 correlates with M2 macrophage phenotype in triple negative breast cancer. Int J Mol Sci. 2021; 22(7): 3764.

9. Kutryb-Zajac B, Jablonska P, Serocki M, Bulinska A, Mierzejewska P, Friebe D, Alter C, Jasztal A, Lango R, Rogowski J, Bartoszewski R, Slominska E, Chlopicki S, Schrader J, Yacoub M, Smolenski RT. Nucleotide ecto-enzyme metabolic pattern and spatial distribution in calcific aortic valve disease: its relation to pathological changes and clinical presentation. Clin Res cardiol. 2020; 109(2): 137-160.

10. Olkowicz M, Debski J, Jablonska P, Dadlez M, Smolenski RT. Application of a new procedure for liquid chromatography/mass spectrometry profiling of plasma amino acid-related metabolites and untargeted shotgun proteomics to identify mechanisms and biomarkers of calcific aortic stenosis. J Chromatogr A. 2017; 1517: 66-78.