Subject Area and Research Team: VIII. Flow cytometry for analysis of cellular pattern and function of the immune system
Research topics
1. Search for biomarkers of physiological and pathological (successful and unsuccessful) ageing
2. Search for biomarkers (predictive and diagnostic) of chronic, ageing-related diseases (autoimmune) including connective tissue diseases, neurodegenerative, and haematological malignancies
3. Search for biomarkers predictive of therapeutic success in individual patients obtaining biologics (personalized medicine)
4. Identification of interaction between phagocytes and bacteria as predictors of infectious disease severity
5. Assessment of parameters and functionality of innate immune system in patients receiving anti-CD20 immunotherapy
6. Search for rare variants of complement genes in chronic kidney diseases
Coordinators
| Coordinator #1 | Coordinator #2 | |
|---|---|---|
| Name and surname |  |
 |
| Academic degree | Prof. Dr. Habil. | Prof. Dr. Habil. |
| Employment unit | Department of Physiopathology | Division of Pathology and Experimental Rheumatology |
| Polish Platform of Medical Research | Prof. Dr. Habil. Jacek Witkowski | Prof. Dr. Habil. Ewa Bryl |
| jacek.witkowski@gumed.edu.pl | ewa.bryl@gumed.edu.pl | |
| Phone number | +48 58 349 15 10 | +48 58 349 15 10 |
Research Team VIII. Flow cytometry for analysis of cellular pattern and function of the immune system
Team Members VIII. Flow cytometry for analysis of cellular pattern and function of the immune system (132 KB)Feel free to contact our coordinator to join the Research Team.
Key current projects
1. Participation of limited intracellular proteolysis in regulation of immune cell function in health and disease
Key grants
| Funding agency/grant number | Title of the project | Years | |
|---|---|---|---|
| 1. | None active | - | - |
International cooperation
| Foreign partner (unit name) | Principal investigator(s) | Area of cooperation | |
|---|---|---|---|
| 1. | University of Sherbrooke, Quebec, Canada | Tamas Fulop | 1. Search for biomarkers of physiological and pathological (successful and unsuccessful) ageing
2. Search for biomarkers (predictive and diagnostic) of chronic, ageing-related diseases (autoimmune including connective tissue diseases, neurodegenerative, and haematological malignancies |
| 2. | Centre of Biological Research, Madrid, Spain | Santiago Rodriguez de Córdoba | Search for rare genetic variants of complement genes in rare kidney diseases |
Key publications
1. Witkowski JM, Bryl E, Fulop T. Proteodynamics and aging of eukaryotic cells. Mech Ageing Dev. 2021; 194: 111430.
2. Marcinkiewicz J, Witkowski JM, Olszanecki R. The dual role of the immune system in the course of COVID-19. The fatal impact of the aging immune system. Cent Eur J Immunol. 2021; 46(1): 1-9.
3.Fulop T, Larbi A, Hirokawa K, Cohen AA, Witkowski JM. Immunosenescence is both functional/adaptive and dysfunctional/maladaptive. Semin Immunopathol. 2020; 42(5): 521-536.
4. Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev. 2020; 191: 111316.
5. Łopatniuk P, Puchalska Z, Mital A, Mikosik A, Frąckowiak J, Hellmann A, Daca A, Bryl E, Fulop T, Witkowski JM. Excessive amount and activity of μ-calpain affects apoptotic machinery in chronic B-cell leukemia cells and influences the course of the disease. Acta Biochim Pol. 2020; 67(2): 247-257..
6. Witkowski JM, Larbi A, Le Page A, Fülöp T. Natural Killer Cells, Aging, and Vaccination. Interdiscip Top Gerontol Geriatr. 2020; 43: 18-35.
7. Fülöp T, Munawara U, Larbi A, Desroches M, Rodrigues S, Catanzaro M, Guidolin A, Khalil A, Bernier F, Barron AE, Hirokawa K, Beauregard PB, Dumoulin D, Bellenger JP, Witkowski JM, Frost E. Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease. CNS Drugs. 2020; 34(7): 673-695.
8. Witkowski JM, Bryl E, Fulop T. Should we Try to Alleviate Immunosenescence and Inflammaging – Why, How and to What Extent? Curr Pharm Des. 2019; 25(39):4154-4162.
9. Fulop T, Witkowski JM, Olivieri F, Larbi A. The integration of inflammaging in age-related diseases. Semin Immunol. 2018; 40: 17-35.
10. Stasiłojć G, Felberg A, Urban A, Kowalska D, Ma S, Blom AM, Lundin J, Osterborg A, Okrój M. Calcein release assay as a method for monitoring serum complement activity during monoclonal antibody therapy in patients with B-cell malignancies. J Immunol Meth. 2020; 476: 112675.