Subject Area and Research Team: VII. Metabolic dynamics and oxidative stress pattern analysis
Research topics
In vitro and in vivo studies regarding:
1. The study of cellular energy metabolism in cancer and neurodegeneration: determination of the concentration levels of key metabolites in various metabolic and signaling pathways, enzyme activities as well as gene expression and post-translational protein modification in different cellular compartments as observed in pathology
2. Nitro-oxidative stress in pathogenesis, progression and treatment of cancer and neurodegeneration processes
3. Metabolism of nutrients (vitamins, microelements, etc.)
4. Biological reactivity evaluation based on computational analysis of structure and unique chemistry (electrophilic potential, lipophilicity) of natural and synthetic low molecular organic compounds in terms of oxidative stress phenomena with potential applicability in treatment of different pathologies (cancer, preeclampsia)
5. Mitochondria function and dynamics as potential target for anticancer agents
Coordinators
| Coordinator #1 | Coordinator #2 | |
|---|---|---|
| Name and surname |  |
 |
| Academic degree | Assoc. Prof. Dr. Habil. | Dr. Habil. |
| Employment unit | Department of Medical Chemistry | Department of Laboratory Medicine |
| Polish Platform of Medical Research | Assoc. Prof. Magdalena Górska-Ponikowska Dr. Habil. | Dr. Habil. Agnieszka Jankowska-Kulawy |
| magdalena.gorska-ponikowska@gumed.edu.pl | agnieszka.jankowska-kulawy@gumed.edu.pl | |
| Phone number | +48 58 349 14 50 | +48 58 349 27 70 |
Research Team VII. Metabolic dynamics and oxidative stress pattern analysis
Team Members VII. Metabolic dynamics and oxidative stress pattern analysis (157 KB)Feel free to contact one of our coordinators to join our Research Team.
Key current projects
1. Molecular pathways in cancer and neuronal cell death
2. Biomarkers of cancer therapy
3. Different forms of graphene as carrier of selected anticancer drugs
Key grants
| Funding agency/grant number | Title of the project | Years | |
|---|---|---|---|
| 1. | NCN, OPUS 19, 2020/37/B/NZ7/01794 |
Effect of time restrictions in food intaking and endurance training on older women’s health markers | 2021-2025 |
| 2. | Innovation Incubator 4.0. The funds come from the non-competitive project Support for the management of scientific research and commercialization of R&D results in research units and enterprises, implemented under the Intelligent Development Operational Program 2014-2020 (section 4.4) | Graphene nanoflakes as carrier of selected anticancer drugs in therapy of malignant tumors | 2021-2022 |
| 3. | NCN, PRELUDIUM 15, 2018/29/N/NZ7/01627 |
Effect of swimming training on autophagy and oxidative stress in the spinal cord of mice with Amyotrophic Lateral Sclerosis | 2018-2021 |
| 4. | NCN, PRELUDIUM 18, 2019/35/N/NZ7/03757 |
Effect of omega-3 supplementation on stress-induced mood and kinurenine metabolism in physically active and physically inactive men | 2021-2023 |
| 5. | Ministry of Science and Higher Education Iuventus Plus, IP2015 022074 |
Mitochondrial biogenesis and mitofagia as a potential target of anti-cancer action of 2-methoxyestradiol | 2016-2021 |
International cooperation
| Foreign partner (unit name) | Principal investigator(s) | Area of cooperation | |
|---|---|---|---|
| 1. | University of Palermo, Palermo, Italy | Francesco Cappello | Heat shock proteins as biomarkers of efficacy of anticancer agents |
| 2. | McMaster University, Hamilton, Canada | Mark Tarnopolsky and Gianni Parise | Oxidative stress in neuromuscular diseases and amyotrophic lateral sclerosis |
| 3. | University of Stuttgart, Stuttgart, Germany | Stephan Nussberger | Mitochondria dynamics and function |
| 4. | Università Politecnica delle Marche, Ancona, Italy | Luca Tiano Elizabetta Damiani
Lucedio Greci Enrico Bertoli |
Exercise metabolism -role of CoQ10 in adaptation process
Molecular design and synthesis of low molecular antioxidants. Biochemistry of natural antioxidants and nutrition |
Key publications
1. Gorska-Ponikowska M, Ploska A, Jacewicz D, Szkatula M, Barone G, Lo Bosco G, Lo Celso F, Dabrowska AM, Kuban-Jankowska A, Gorzynik-Debicka M, Knap N, Chmurzynski L, Dobrucki LW, Kalinowski L, Wozniak M. Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol-induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells. Redox Biol. 2020; 32: 101522.
2. Gorska-Ponikowska M, Bastian P, Zauszkiewicz-Pawlak A, Ploska A, Zubrzycki A, Kuban-Jankowska A, Nussberger S, Kalinowski L, Kmiec Z. Regulation of mitochondrial dynamics in 2-methoxyestradiol-mediated osteosarcoma cell death. Sci Rep. 2021; 11(1): 1616.
3. Zabul P, Wozniak M, Slominski AT, Preis K, Gorska M, Korozan M, Wieruszewski J, Zmijewski MA, Zabul E, Tuckey R, Kuban-Jankowska A, Mickiewicz W, Knap N. A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia. International Journal of Molecular Sciences. 2015; 16: 13043-13064.
4. Mieszkowski J, Stankiewicz B, Kochanowicz A, Niespodzinski B, Kowalik T, Zmijewski MA, Kowalski K, Rola R, Bienkowski T, Antosiewicz J. Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial. Nutrients. 2020; 12(12): 3629.
5. Halon-Golabek M, Borkowska A, Kaczor JJ, Ziolkowski W, Flis DJ, Knap N, Kasperuk K, Antosiewicz J. hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway. J Cachexia Sarcopenia Muscle. 2018; 9: 557-569.
6. Ronowska A, Gul-Hinc S, Michno A, Bizon-Zygmańska D, Zyśk M, Bielarczyk H, Szutowicz A, Gapys B, Jankowska-Kulawy A. Aggravated effects of coexisting marginal thiamine deficits and zinc excess on SN56 neuronal cells. Nutritional Neuroscience. 2019; 432-442.
7. Kutryb-Zajac B, Koszalka P, Mierzejewska P, Bulinska A, Zabielska MA, Brodzik K, Skrzypkowska A, Zelazek L, Pelikant-Malecka I, Slominska EM, Smolenski RT. Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms. J Cell Mol Med. 2018; 22(12): 5939-5954.
8. Kasztan M, Piwkowska A, Kreft E, Rogacka D, Audzeyenka I, Szczepanska-Konkel M, Jankowski M. Extracellular purines’ action on glomerular albumin permeability in isolated rat glomeruli: insights into the pathogenesis of albuminuria. Am J Physiol Renal Physiol. 2016; 311(1): F103-11.