Subject Area and Research Team: VII. Metabolic dynamics and oxidative st...

Subject Area and Research Team: VII. Metabolic dynamics and oxidative stress pattern analysis



Research topics

In vitro and in vivo studies regarding:

1. The study of cellular energy metabolism in cancer and neurodegeneration: determination of the concentration levels of key metabolites in various metabolic and signaling pathways, enzyme activities as well as gene expression and post-translational protein modification in different cellular compartments as observed in pathology

2. Nitro-oxidative stress in pathogenesis, progression and treatment of cancer and neurodegeneration processes

3. Metabolism of nutrients (vitamins, microelements, etc.)

4. Biological reactivity evaluation based on computational analysis of structure and unique chemistry (electrophilic potential, lipophilicity) of natural and synthetic low molecular organic compounds in terms of oxidative stress phenomena with potential applicability in treatment of different pathologies (cancer, preeclampsia)

5. Mitochondria function and dynamics as potential target for anticancer agents

Coordinators

Coordinator #1 Coordinator #2
Name and surname
dr_Górska-Ponikowska.jpeg
Magdalena Górska-Ponikowska
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Agnieszka Jankowska-Kulawy
Academic degree Assoc. Prof. Dr. Habil. Dr. Habil.
Employment unit Department of Medical Chemistry Department of Laboratory Medicine
Polish Platform of Medical Research Assoc. Prof. Magdalena Górska-Ponikowska Dr. Habil. Dr. Habil. Agnieszka Jankowska-Kulawy
Email magdalena.gorska-ponikowska@gumed.edu.pl agnieszka.jankowska-kulawy@gumed.edu.pl
Phone number +48 58 349 14 50 +48 58 349 27 70


Research Team VII. Metabolic dynamics and oxidative stress pattern analysis

Team Members VII. Metabolic dynamics and oxidative stress pattern analysis (155 KB)


Feel free to contact one of our coordinators to join our Research Team.

Key current projects

1. Molecular pathways in cancer and neuronal cell death

2. Biomarkers of cancer therapy

3. Different forms of graphene as carrier of selected anticancer drugs

Key grants

Funding agency/grant number Title of the project Years
1. NCN, OPUS 19,
2020/37/B/NZ7/01794
Effect of time restrictions in food intaking and endurance training on older women’s health markers 2021-2025
2. Innovation Incubator 4.0. The funds come from the non-competitive project Support for the management of scientific research and commercialization of R&D results in research units and enterprises, implemented under the Intelligent Development Operational Program 2014-2020 (section 4.4) Graphene nanoflakes as carrier of selected anticancer drugs in therapy of malignant tumors 2021-2022
3. NCN, PRELUDIUM 15,
2018/29/N/NZ7/01627
Effect of swimming training on autophagy and oxidative stress in the spinal cord of mice with Amyotrophic Lateral Sclerosis 2018-2021
4. NCN, PRELUDIUM 18,
2019/35/N/NZ7/03757
Effect of omega-3 supplementation on stress-induced mood and kinurenine metabolism in physically active and physically inactive men 2021-2023
5. Ministry of Science and Higher Education Iuventus Plus,
IP2015 022074
Mitochondrial biogenesis and mitofagia as a potential target of anti-cancer action of 2-methoxyestradiol 2016-2021

International cooperation

Foreign partner (unit name) Principal investigator(s) Area of cooperation
1. University of Palermo, Palermo, Italy Francesco Cappello Heat shock proteins as biomarkers of efficacy of anticancer agents
2. McMaster University, Hamilton, Canada Mark Tarnopolsky and Gianni Parise Oxidative stress in neuromuscular diseases and amyotrophic lateral sclerosis
3. University of Stuttgart, Stuttgart, Germany Stephan Nussberger Mitochondria dynamics and function
4. Università Politecnica delle Marche, Ancona, Italy Luca Tiano Elizabetta Damiani

Lucedio Greci Enrico Bertoli
Exercise metabolism -role of CoQ10 in adaptation process

Molecular design and synthesis of low molecular antioxidants. Biochemistry of natural antioxidants and nutrition
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Key publications

1. Gorska-Ponikowska M, Ploska A, Jacewicz D, Szkatula M, Barone G, Lo Bosco G, Lo Celso F, Dabrowska AM, Kuban-Jankowska A, Gorzynik-Debicka M, Knap N, Chmurzynski L, Dobrucki LW, Kalinowski L, Wozniak M. Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol-induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells. Redox Biol. 2020; 32: 101522.

2. Gorska-Ponikowska M, Bastian P, Zauszkiewicz-Pawlak A, Ploska A, Zubrzycki A, Kuban-Jankowska A, Nussberger S, Kalinowski L, Kmiec Z. Regulation of mitochondrial dynamics in 2-methoxyestradiol-mediated osteosarcoma cell death. Sci Rep. 2021; 11(1): 1616.

3. Zabul P, Wozniak M, Slominski AT, Preis K, Gorska M, Korozan M, Wieruszewski J, Zmijewski MA, Zabul E, Tuckey R, Kuban-Jankowska A, Mickiewicz W, Knap N. A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia. International Journal of Molecular Sciences. 2015; 16: 13043-13064.

4. Mieszkowski J, Stankiewicz B, Kochanowicz A, Niespodzinski B, Kowalik T, Zmijewski MA, Kowalski K, Rola R, Bienkowski T, Antosiewicz J. Ultra-Marathon-Induced Increase in Serum Levels of Vitamin D Metabolites: A Double-Blind Randomized Controlled Trial. Nutrients. 2020; 12(12): 3629.

5. Halon-Golabek M, Borkowska A, Kaczor JJ, Ziolkowski W, Flis DJ, Knap N, Kasperuk K, Antosiewicz J. hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway. J Cachexia Sarcopenia Muscle. 2018; 9: 557-569.

6. Ronowska A, Gul-Hinc S, Michno A, Bizon-Zygmańska D, Zyśk M, Bielarczyk H, Szutowicz A, Gapys B, Jankowska-Kulawy A. Aggravated effects of coexisting marginal thiamine deficits and zinc excess on SN56 neuronal cells. Nutritional Neuroscience. 2019; 432-442.

7. Kutryb-Zajac B, Koszalka P, Mierzejewska P, Bulinska A, Zabielska MA, Brodzik K, Skrzypkowska A, Zelazek L, Pelikant-Malecka I, Slominska EM, Smolenski RT. Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms. J Cell Mol Med. 2018; 22(12): 5939-5954.

8. Kasztan M, Piwkowska A, Kreft E, Rogacka D, Audzeyenka I, Szczepanska-Konkel M, Jankowski M. Extracellular purines’ action on glomerular albumin permeability in isolated rat glomeruli: insights into the pathogenesis of albuminuria. Am J Physiol Renal Physiol. 2016; 311(1): F103-11.