Subject Area and Research Team: VI. Organ toxicity of cancer treatment
Research topics
1. Early and late effects of childhood and adolescent cancer treatment and their impact on quality of life with focus on fertility, ototoxicity, malnutrition, sarcopenia and sarcopenic obesity, infectious complications
2. Mechanisms of treatment-related cardiotoxicity of systemic therapies in cancer patients
3. Vascular endothelial damage and myocardial fibrosis as an early manifestation of the cardiotoxic effects of radiotherapy
4. Skin toxicities of modern oncological therapies; new applications of dermoscopy, genetic risk factors
Coordinators
| Coordinator #1 | Coordinator #2 | |
|---|---|---|
| Name and surname |  |
 |
| Academic degree | Prof. Dr. Habil. | Prof. Dr. Habil. |
| Employment unit | Department of Clinical Oncology and Radiotherapy | Department of Cardiology and Electrotherapy |
| Polish Platform of Medical Research | Prof. Dr. Habil. Renata Zaucha | Prof. Dr. Habil. Ewa Lewicka |
| renata.zaucha@gumed.edu.pl | ewa.lewicka@gumed.edu.pl | |
| Phone number | +48 58 349 45 10 | +48 58 349 39 10 |
Research Team: VI. Organ toxicity of cancer treatment
Team Members: VI. Organ toxicity of cancer treatment.pdf (194 KB)Feel free to contact one of our coordinators to join our Research Team.
Key current projects
1. PanCare studies on fertility and ototoxicity to improve quality of life after cancer during childhood, adolescence and young adulthood.
2. Malnutrition, sarcopenia and sarcopenic obesity in paediatric malignancies during and after treatment
3. Pharmacokinetic analysis of selected cytotoxic and targeted therapeutics in cancer patients of developmental age
4. Vascular endothelial damage and myocardial fibrosis as an early manifestation of the cardiotoxic effects of radiotherapy on the right ventricle in lung cancer patients administered thoracic radiotherapy
5. New applications of dermoscopy in the diagnosis and monitoring of treatment-related skin toxicities
Key grants
| Funding agency/grant number | Title of the project | Years | |
|---|---|---|---|
| 1. | The European Union/ HEALTH-F2-2013-602030 | PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood | 2013-2018 |
| 2. | Polish Ministry of Health/ 1/12/20/2019/25/727 | Program of Assessing the Quality of Life and Health Condition of Children and Adolescents after Anticancer Treatment | 2019-2021 |
| 3. | NCN Miniatura 4 Nr 2020/04/X/NZ5/00387 | Vascular endothelial damage and myocardial fibrosis as an early manifestation of the cardiotoxic effects of radiotherapy on the right ventricle in lung cancer patients administered thoracic radiotherapy | 2020-2021 |
International cooperation
| Foreign partner (unit name) | Principal investigator(s) | Area of cooperation | |
|---|---|---|---|
| 1. | Medical University Berlin, Charité Centre for Women, Children and Adolescent Medicine with Perinatal Centre and Human Genetics, Otto-Heubner-Centre of Child and Adolescent Medicine, Department of Paediatrics, Division of Oncology/Haematology/Stem Cell Transplantation, Campus Virchow Berlin | Anja Borgmann-Staudt, Ralph Schilling | Intervention study – Patient Education, a component study of the 5-year, EU-funded consortium PanCareLIFE |
| 2. | Boyne Research Institute, 5 Bolton Square, East, Drogheda, Co. Louth A92 RY6K, Ireland | Julianne Byrne | Intervention study – Patient Education, a component study of the 5-year, EU-funded consortium PanCareLIFE |
Key publications
1. Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall’Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, Covezzoli A, Brugières L, Perilongo G, Czauderna P, Morland B, Neuwelt EA. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. N Engl J Med. 2018; vol. 378: p. 2376-2385.
2. Sławiński G, Wrona A, Dąbrowska-Kugacka A, Raczak G, Lewicka E. Immune Checkpoint Inhibitors and Cardiac Toxicity in Patients Treated for Non-Small Lung Cancer: A Review. Int J Mol Sci. 2020; vol. 21: p. 7195
3. Maliszewska O, Plenis A, Olędzka I, Kowalski P, Miękus N, Bień E, Krawczyk MA , Adamkiewicz-Drożynska E, Bączek T. Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies. J Pharm Biomed Anal. 2018; vol. 158: p. 376-385.
4. Byrne J, Grabow D, Campbell H, (…), Stefanowicz J, et al. PanCareLIFE: the scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents. Eur. J. Cancer; 2018; vol. 103: p. 227-237.
5. Borgmann-Staudt A, Kunstreich M, Schilling R, et al. Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients. Psycho-Oncology 2019; vol. 28: p. 2218-2225.