Area and Research Team: IX. Neurovascular and stroke medicine
Research topics
1. Novel reperfusion therapeutic approaches in acute ischemic stroke
2. Novel neuroimaging strategies and approaches in acute stroke. Modelling of functional and tissue stroke outcomes and response to therapies with combined molecular, neuroimaging and clinical markers
3. Arterial and cardiac pathophysiology in stroke risk, course and prognosis
4. Biomathematical modelling of stroke prevention and management strategies for Poland
5. Brain metabolism in acute focal ischemia and in chronic cerebral hypoperfusion
Coordinators
| Coordinator #1 | Coordinator #2 | |
|---|---|---|
| Name and surname |  |
 |
| Academic degree | Prof. Dr. Habil. | Dr. Habil. |
| Employment unit | Department of Neurology | 2nd Division of Radiology |
| Polish Platform of Medical Research | Prof. Dr. Habil. Bartosz Karaszewski | Dr. Habil. Arkadiusz Szarmach |
| bartosz.karaszewski@gumed.edu.pl | arkadiusz.szarmach@gumed.edu.pl | |
| Phone number | +48 58 34 923 00 | +48 58 34 936 80 |
photos Paweł Sudara/MUG
Research Team: IX. Neurovascular and stroke medicine
Team Members: IX. Neurovascular and stroke medicine (158 KB)Feel free to contact one of our coordinators to join our Research Team.
Key current projects
1. Pharmacological reperfusion therapy of acute ischemic stroke in patients receiving oral anticoagulants – a multicenter clinical trial
2. Identification of blood, neuroimaging and clinical biomarkers for prospective assessment of the risk of intracranial hemorrhage (ICH) after thrombolytic treatment of acute ischemic stroke
3. Predictive value of arterial stiffness and ventricular – arterial coupling in acute ischemic stroke
4. Local metabolic pathways in focal brain ischemia: relation to tissue and clinical outcomes
5. Biomarkers of early brain pathology of vascular origin
Key grants
| Funding agency/grant numer | Title of the project | Years | |
|---|---|---|---|
| 1. | MEDICAL RESEARCH AGENCY | Pharmacological reperfusion therapy of acute ischemic stroke in patients receiving oral anticoagulants (PI – Bartosz Karaszewski) | 2020-2026 |
| 2. | SIEMENS HEALTHCARE | Identification of blood, neuroimaging and clinical biomarkers for prospective assessment of the risk of intracranial hemorrhage (ICH) after thrombolytic treatment of acute ischemic stroke (PI – Bartosz Karaszewski) | 2018-2021 |
| 3. | NUTRICIA | Optimalization of nutrition supply in patients with dysphagia in the early phase of stroke (PI – Bartosz Karaszewski) | 2017-2019 |
International cooperation
| Foreign partner (unit name) | Principal investigator(s) | Area of cooperation | |
|---|---|---|---|
| 1. | HOSPITAL SENHORA DA OLIVEIRA, GUIMARÃES AND LIFE AND HEALTH SCIENCES RESEARCH INSTITUTE, UNIVERSITY OF MINHO, PORTUGAL | PePhDo Guimarães Cunha | Arterial and cardiac pathophysiology in stroke risk, course and prognosis (PI – DG) | 2. | UNIVERSITY COLLEGE LONDON, NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY | David Werring | Pharmacological reperfusion therapy of acute ischemic stroke in patients receiving oral anticoagulants (PI – BK) |
| 3. | DEPARTMENT OF PHARMACOLOGY AND INSERM U970, HEGP, UNIVERSITE´ PARIS DECARTES, FRANCE | Pierre Boutouyrie, Stephane Laurent | Arterial and cardiac pathophysiology in stroke risk, course and prognosis (PI – DG) |
Key publications
1. Karaszewski B, Houlden H, Smith EE, Markus HS, Charidimou A, Levi C, Werring DJ. What causes intracerebral bleeding after thrombolysis for acute ischaemic stroke? Recent insights into mechanisms and potential biomarkers. Journal of Neurology, Neurosurgery and Psychiatry 2015;86:1127-36
2. Kwarciany M, Gąsecki D, Kowalczyk K, Rojek A, Laurent S, Boutouyrie P, Skrzypek-Czerko M, Nyka WM, Narkiewicz K, Karaszewski B. Acute hypertensive response in ischemic stroke is associated with increased aortic stiffness. Atherosclerosis 2016;251:1-5
3. Gąsecki D, Coca A, Cunha P, Hering D, Manios E, Lovic D, Zaninelli A, Sierra C, Kwarciany M, Narkiewicz K, Karaszewski B. Journal of Hypertension 2018;36:1212-21
4. Gójska-Grymajło A, Zieliński M, Wardowska A, Gąsecki D, Pikuła M, Karaszewski B. CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients. Neurochemistry International 2018;120:134-9