Subject Area and Research Team: VII. Cardionephrology

Area and Research Team: VII. Cardionephrology


Research topics

1. Dyslipidemia as a major risk factor for cardio-vascular complications in patients – clinical and epidemiological studies

2. Pharmacological blockade of the renin-angiotensin-aldosterone system (RAAS) in CKD patients

3. Autosomal Dominant Polycystic Kidney Disease (ADPKD) – prognostic factors and clinical outcome

4. Factors affecting outcome in children receiving chronic renal replacement therapy for end-stage renal disease across Europe – registry studies

Coordinators

Coordinator #1 Coordinator #2
Name and surname
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Michał Chmielewski
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Ilona Zagożdżon
Academic degree Prof. Dr. Habil. Ph.D.
Employment unit Dept of Nephrology, Transplantology and Internal Medicine Dept of Pediatrics, Nephrology and Hypertension
Polish Platform of Medical Research Prof. Dr. Habil. Michał Chmielewski Ilona Zagożdżon, Ph.D.
Email michal.chmielewski@gumed.edu.pl ilona.zagozdzon@gumed.edu.pl
Phone number +48 58 34 925 05 +48 58 34 928 50

photos Paweł Sudara/MUG


Research Team: VII. Cardionephrology

Team Members: VII. Cardionephrology (159 KB)


Feel free to contact one of our coordinators to join our Research Team.

Key current projects

1. Mechanisms diminishing cardio-vascular risk in end-stage renal disease patients undergoing kidney transplantation

2. Cardiovascular phenotype of adult and pediatric patients with autosomal dominant polycystic kidney disease

3. Acute kidney injury and renal replacement therapies after cardiovascular surgery

4. The role of abnormalities of fatty acids profile in chronic kidney disease

5. Phenotype-genotype correlations in familial hematuria (Alport Syndrome and Thin Basemen Membrane Nephropathy)

Key grants

Funding agency/grant numer Title of the project Years
1. National Science Centre NCN: 2013/11/B/NZ5/00118 The role of abnormalities of fatty acids profile in chronic kidney disease 2014-2018
2. National Science Centre NCN: 2017/25/N/NZ5/00466 Phenotype-genotype correlations in familial hematuria 2017-ongoing
3. National Science Centre NCN:2018/30/M/NZ5/00480 Bone-mineral phenotype in ADPKD patients 2019-onging

International cooperation

Foreign partner (unit name) Principal investigator(s) Area of cooperation
1. Katholieke University of Leuven, Belgium Prof Pieter Evenenepoel Chronic kidney dsease
2. ESPN/ERA-EDTA Registry Amsterdam University, Nethrlands Kitty Jager Data of National Registries of Children with Stage 5 Chronic Kidney Disease
3. Heidelberg University, Germany Prof. Franz Schaefer Cardiovascular Comorbidity in Children With Chronic Kidney Disease (4C) Study
4. Charité – Universitätsmedizin, Berlin, Germany Prof Klemens Budde Arterial stiffness in renal transplant recipients
5. Karolinska Institutet, Stockholm Sweden Prof Peter Stenvinkel, Prof Bengt Lindholm Atherosclerosis in chronic kidney disease
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Key publications

1. Chmielewski M, Korczyńska J, Śledziński M, Czaplińska M, Dębska-Ślizień A, Mika A: Contribution of increased expression of stearoyl-CoA desaturase-1 in adipose tissue to serum content of monounsaturated fatty acids in patients with chronic kidney disease. Pol Arch Intern Med. 2019;129(9):641-644.

2. Czaplińska M, Ćwiklińska A, Sakowicz-Burkiewicz M, Wieczorek E, Kuchta A, Kowalski R, Kortas-Stempak B, Dębska-Ślizień A, Jankowski M, Król E: Apolipoprotein E gene polymorphism and renal function are associated with apolipoprotein E concentration in patients with chronic kidney disease. Lipids Health Dis. 2019;18(1):60.

3. Mika A, Sikorska-Wiśniewska M, Małgorzewicz S, Stepnowski P, Dębska-Ślizień A, Śledziński T, Chmielewski M.: Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease. Pol Arch Intern Med. 2018;128(12): 755-763

4. Kuźmiuk-Glembin I, Adrych D, Tylicki L, Heleniak Z, Garnier H, Wiśniewski J, Rutkowski P, Rutkowski B, Dębska-Ślizień A. Treatment of hypertension in renal transplant recipients in four independent cross-sectional analyses Kidney Blood Press Res. 2018;43(1):45-54.

5. Chesnaye NC, Schaefer F, Bonthuis M , Holman R, Baiko S, Baskın E, Bjerre A, Cloarec S, Cornelissen EAM, Espinosa L, Heaf J, Stone R,Shtiza D, Zagozdzon I , Harambat J, Jager KJ, Groothoff JW, van Stralen KJ, ESPN/ERA-EDTA Registry Committee.: Mortality risk disparities in children receiving chronic renal replacement therapy for the treatment of end-stage renal disease across Europe: an ESPN-ERA/EDTA registry analysis. Lancet, 2017;389(10084):2128-2137.