Subject Area and Research Team: II. Cardiovascular regulation in health ...

Subject Area and Research Team: II. Cardiovascular regulation in health and disease


Research topics

1. Role of sympathetic nervous system in development and progression of cardiovascular disease

2. Cardiorespiratory coupling in health and disease

3. Blood-brain barrier in health and disease

4. Brain perfusion, function and structure – impact of exercise and hypertension

5. Environmental (hyperbaric) neuropsychology

6. Iron metabolism

Coordinators

Coordinator #1 Coordinator #2
Name and surname
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Krzysztof Narkiewicz
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Paweł Winklewski
Academic degree Prof. Dr. Habil. Prof. Dr. Habil.
Employment unit Department of Hypertension and Diabetology Department of Human Physiology
Polish Platform of Medical Research Prof. Dr. Habil. Krzysztof Narkiewicz Prof. Dr. Habil. Paweł Winklewski
Email krzysztof.narkiewicz@gumed.edu.pl pawel.winklewski@gumed.edu.pl
Phone number +48 58 34 925 27 +48 58 34 915 15

photos Paweł Sudara/MUG


Team Members II. Cardiovascular regulation in health and disease

Team Members: II. Cardiovascular regulation in health and disease (150 KB)


Feel free to contact one of our coordinators to join our Research Team.

Key current projects

1. Alterations in breathing pattern and cardiorespiratory coupling as a novel mechanism leading to autonomic imbalance in cardiovascular diseases

2. Hypertension and cerebrovascular dysfunction

3. Effect of therapy with selective serotonin reuptake inhibitors and physical exercise on blood brain barrier permeability, selected brain neurotransmitters, kinurenine pathway and mood in major depressive disorder

4. Impact of exercise training on structural and functional brain changes among the elderly

5. Effect of hyperbaric environment on cognition

6. Changes in iron metabolism and vitamin D induced by physical exercise

Key grants

Funding agency/grant numer Title of the project Years
1. NCN MAESTRO Hypertension and cerebrovascular dysfunction 2013-2018
2. NCN OPUS Alterations in breathing pattern and cardiorespiratory coupling as a novel mechanism leading to autonomic imbalance in cardiovascular diseases 2019-2022
3. NCN OPUS The impact of aerobic and resistance interval training on structural as well as functional brain changes among the elderly – the role of myokines, cytokines and trophic factors 2020-2023
4. NCN PRELUDIUM Effect of therapy with selective serotonin reuptake inhibitors and physical exercise on blood brain barrier permeability, selected neurotransmitters in prefrontal cortex and hippocampus, kinurenine pathway and mood in major depressive disorder 2020-2023

International cooperation

Foreign partner (unit name) Principal investigator(s) Area of cooperation
1. Mayo Clinics, Rochester, USA Virend K. Somers Sympathetic neural mechanisms
2. Faculty of Kinesiology and Health Studies, University of Regina, Canada Prof. Patrick Neary Hypobaric hypoxia and brain oxygenation
3. INSERM, Paris, France Pierre Boutoyrie/Stephane Laurent Early vascular aging
4. University of Leuven, Leuven, Belgium Jan Staessen Population-based studies
5. University of Lund, Sweden Olle Melander/Peter Nilsson Novel cardiovascular risk factors
6. Laboratory of Exercise Biochemistry and Neuroendocrinology Advanced Research Initiative for Human High Performance Faculty of Sports and Health and Sports Sciences University of Tsukuba, Japan Prof. Hideaki Soya Exercise, brain oxygenation and cognition
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Key publications

1. Małkiewicz MA, Szarmach A, Sabisz A, Cubała WJ, Szurowska E, Winklewski PJ. Blood-brain barrier permeability and physical exercise. J Neuroinflammation. 2019;16:15.

2. Winklewski PJ, Wolf J, Gruszecki M, Wszedybyl-Winklewska M, Narkiewicz K. Current understanding of the effects of inspiratory resistance on the interactions between systemic blood pressure, cerebral perfusion, intracranial pressure, and cerebrospinal fluid dynamics. J Appl Physiol. 2019;127:1206-1214.

3. Wszedybyl-Winklewska M, Wolf J, Szarmach A, Winklewski PJ, Szurowska E, Narkiewicz K. Central sympathetic nervous system reinforcement in obstructive sleep apnoea. Sleep Med Rev. 2018;39:143-154.

4. Winklewski PJ, Sabisz A, Naumczyk P, Jodzio K, Szurowska E, Szarmach A. Understanding the Physiopathology Behind Axial and Radial Diffusivity Changes-What Do We Know? Front Neurol. 2018;9:92.

5. Hering D, Kucharska W, Chrostowska M, Narkiewicz K. Age-dependent sympathetic neural responses to ß1 selective beta-blockade in untreated hypertension-related tachycardia. Blood Press. 2018 ; 27: 158-165.

6. Naumczyk P, Sabisz A, Witkowska M, Graff B, Jodzio K, Gąsecki D, Szurowska E, Narkiewicz K. Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study. J Hypertens. 2017; 35:1252-1262.